Nishimura Koichi, Nakayasu Kazuhito, Mori Mio, Sanda Ryo, Shibayama Ayumi, Kusunose Masaaki
Department of Respiratory Medicine, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Data Research Section, Kondo Photo Process Co., Ltd., Osaka 543-0011, Japan.
Diagnostics (Basel). 2021 Nov 2;11(11):2029. doi: 10.3390/diagnostics11112029.
Although there have been many published reports on fatigue and pain in patients with chronic obstructive pulmonary disease (COPD), it is considered that these symptoms are seldom, if ever, asked about during consultations in Japanese clinical practice. To bridge this gap between the literature and daily clinical experience, the authors attempted to gain a better understanding of fatigue and pain in Japanese subjects with COPD. The Brief Fatigue Inventory (BFI) to analyse and quantify the degree of fatigue, the revised Short-Form McGill Pain Questionnaire 2 (SF-MPQ-2) for measuring pain and the Kihon Checklist to judge whether a participant is frail and elderly were administered to 89 subjects with stable COPD. The median BFI and SF-MPQ-2 Total scores were 1.00 [IQR: 0.11-2.78] and 0.00 [IQR: 0.00-0.27], respectively. They were all skewed toward the milder end of the respective scales. A floor effect was noted in around a quarter on the BFI and over half on the SF-MPQ-2. The BFI scores were significantly different between groups regarding frailty determined by the Kihon Checklist but not between groups classified by the severity of airflow limitation. Compared to the literature, neither fatigue nor pain are considered to be frequent, important problems in a real-world Japanese clinical setting, especially among subjects with mild to moderate COPD. In addition, our results might suggest that fatigue is more closely related to frailty than COPD.
尽管已有许多关于慢性阻塞性肺疾病（COPD）患者疲劳和疼痛的报道，但在日本临床实践中，人们认为在会诊期间很少（如果有的话）询问这些症状。为了弥合文献与日常临床经验之间的差距，作者试图更好地了解日本COPD患者的疲劳和疼痛情况。对89例稳定期COPD患者进行了用于分析和量化疲劳程度的简明疲劳量表（BFI）、用于测量疼痛的修订版简明麦吉尔疼痛问卷2（SF-MPQ-2）以及用于判断参与者是否虚弱和年老的基本检查表。BFI和SF-MPQ-2总分的中位数分别为1.00[四分位间距：0.11-2.78]和0.00[四分位间距：0.00-0.27]。它们都向各自量表较轻的一端倾斜。在BFI中约四分之一的患者以及SF-MPQ-2中超过一半的患者中发现了地板效应。根据基本检查表确定的虚弱组之间BFI评分有显著差异，但按气流受限严重程度分类的组之间无显著差异。与文献相比，在日本现实临床环境中，疲劳和疼痛都不被认为是常见的重要问题，尤其是在轻度至中度COPD患者中。此外，我们的结果可能表明，疲劳与虚弱的关系比与COPD的关系更密切。
