Gu Feng, Liu Yuming, Liu Yuan, Cheng Shujie, Yang Jihong, Kang Ming, Duan Wendu, Liu Yan
Department of Hepatobiliary, Hospital of HeBei University, Baoding, China.
General Hospital of Huabei Petroleum Administration Bureau, Renqiu, China.
Open Med (Wars). 2020 May 19;15(1):424-434. doi: 10.1515/med-2020-0406. eCollection 2020.
Retinoic acid receptor-related orphan receptors (RORs) are frequently abnormally expressed in several human malignancies, including gastric cancer (GC). RORs are involved in the development and progression of GC through Wnt signaling pathway receptors and other common receptors. However, the prognostic roles of individual RORs in patients with GC remain elusive. We accessed the prognostic roles of three RORs (RORα, RORβ, and RORγ) through "The Kaplan-Meier plotter" (KM plotter) database in patients with GC. For all patients with GC who were followed for 20 years, the low mRNA expression of all three RORs showed a significant correlation with better outcomes. We further accessed the prognostic value of individual RORs in different clinical pathological features including Lauren classification, clinical stages, pathological grades, HER2 status, and different treatments methods. The RORs demonstrated critical prognostic roles in GC. Expressions of RORs were higher in GC tissues when compared with normal gastric tissues. Moreover, knockdown of RORs significantly inhibited cell proliferation and migration, suggesting an oncogenic role of RORs in human GC. These findings suggest potential roles of RORs as biomarkers for GC prognosis and as oncogenes in GC.
维甲酸受体相关孤儿受体（RORs）在包括胃癌（GC）在内的多种人类恶性肿瘤中经常异常表达。RORs通过Wnt信号通路受体和其他常见受体参与GC的发生和发展。然而，单个RORs在GC患者中的预后作用仍不清楚。我们通过“Kaplan-Meier绘图仪”（KM绘图仪）数据库评估了三种RORs（RORα、RORβ和RORγ）在GC患者中的预后作用。对于随访20年的所有GC患者，所有三种RORs的低mRNA表达均与较好的预后显著相关。我们进一步评估了单个RORs在不同临床病理特征（包括Lauren分类、临床分期、病理分级、HER2状态和不同治疗方法）中的预后价值。RORs在GC中显示出关键的预后作用。与正常胃组织相比，GC组织中RORs的表达更高。此外，敲低RORs显著抑制细胞增殖和迁移，表明RORs在人类GC中具有致癌作用。这些发现提示RORs作为GC预后生物标志物和GC癌基因的潜在作用。
