Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.
Applied Technology and Genomics Division, US Air Force School of Aerospace Medicine, Dayton, Ohio, USA.
J Pediatric Infect Dis Soc. 2021 May 28;10(5):695-697. doi: 10.1093/jpids/piaa167.
Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.
儿童多系统炎症综合征（MIS-C）是一种新出现的疾病过程，可使严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染复杂化。我们报告了我们认为是最早的 MIS-C 病例，发生在 2020 年 2 月。我们患者的 SARS-CoV-2 感染是由在刺突蛋白中具有 D614G 变异的新兴谱系引起的。该谱系随后成为欧洲和美国 SARS-CoV-2 暴发的主要原因，而 MIS-C 正是在这些地区首次被描述的。
