Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Nuclear Magnetic Resonance Center, Xi'an Modern Chemistry Research Institute, Xi'an, China.
Nat Prod Res. 2022 Apr;36(8):2118-2124. doi: 10.1080/14786419.2020.1845676. Epub 2020 Dec 18.
The chemical constituent investigation on the starfish resulted in the isolation of two new polyhydroxylated steroidal glycosides and two known ones. The new compounds were identified as (25)-3--(2--methyl--D-xylopyranosyl)-26--(-D-xylopyranosyl)-cholest-4-ene-3,6,7,8,15,16,26-heptaol () and (25)-3--(2--methyl--D-xylopyranosyl)-26--(-D-xylopyranosyl)-cholest-4,24(28)-diene-3,6,7,8,15,16,26-heptaol () and the known compounds were determined as linckosides I and H (-). The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic studies and chemical evidence. In addition, the cytotoxicity of the two new compounds against human glioblastoma cell lines U87, U251 and SHG44 was evaluated by MTT method.
从海星中得到的化学成分研究结果分离得到了两个新的多羟基甾族糖苷和两个已知的化合物。新化合物被鉴定为（25）-3--（2--甲基--D-吡喃木糖基）-26--（-D-吡喃木糖基）-胆甾-4-烯-3,6,7,8,15,16,26-七醇（）和（25）-3--（2--甲基--D-吡喃木糖基）-26--（-D-吡喃木糖基）-胆甾-4,24(28)-二烯-3,6,7,8,15,16,26-七醇（），而已知化合物则被确定为林克索斯 I 和 H（-）。根据广泛的光谱研究和化学证据，确定了分离化合物的结构。此外，通过 MTT 法评估了两种新化合物对人神经胶质瘤细胞系 U87、U251 和 SHG44 的细胞毒性。
