艾滋病相关进行性多灶性白质脑病。
AIDS-related progressive multifocal leukoencephalopathy.
机构信息
Secretaria de Estado da Saúde de Goiás, Hospital de Doenças Tropicais Dr. Anuar Auad, Goiânia, GO, Brasil.
Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Dec 21;54:e02522020. doi: 10.1590/0037-8682-0252-2020. eCollection 2020.
Abstract
INTRODUCTION
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).
METHODS
We described the profile of laboratory-confirmed PML cases among AIDS patients.
RESULTS
A total of 43 HIV patients with clinical conditions compatible with PML were obtained; 5 cases were confirmed by JCV testing. The main clinical finding was mental confusion. Median CD4 count was 54 cells/mm³.
CONCLUSIONS
Three of the five confirmed PML cases died; the time between diagnosis and death was 2, 5, and 6 months. It is important to consider JCV infection as a differential diagnosis.
摘要
简介
进行性多灶性白质脑病（PML）是一种由 JC 病毒（JCV）激活引起的中枢神经系统脱髓鞘疾病。
方法
我们描述了 AIDS 患者中经实验室确诊的 PML 病例的特征。
结果
共获得 43 例 HIV 患者，其临床状况与 PML 相符，其中 5 例通过 JCV 检测得到确诊。主要的临床发现是精神错乱。中位 CD4 计数为 54 个细胞/mm³。
结论
5 例确诊的 PML 病例中有 3 例死亡；从诊断到死亡的时间分别为 2、5 和 6 个月。考虑 JCV 感染作为鉴别诊断非常重要。
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本文引用的文献
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2
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3
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4
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Clin Dev Immunol. 2013;2013:839719. doi: 10.1155/2013/839719. Epub 2013 Apr 17.
5
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Clin Microbiol Rev. 2012 Jul;25(3):471-506. doi: 10.1128/CMR.05031-11.
6
7
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