Secretaria de Estado da Saúde de Goiás, Hospital de Doenças Tropicais Dr. Anuar Auad, Goiânia, GO, Brasil.
Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brasil.
Rev Soc Bras Med Trop. 2020 Dec 21;54:e02522020. doi: 10.1590/0037-8682-0252-2020. eCollection 2020.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).
We described the profile of laboratory-confirmed PML cases among AIDS patients.
A total of 43 HIV patients with clinical conditions compatible with PML were obtained; 5 cases were confirmed by JCV testing. The main clinical finding was mental confusion. Median CD4 count was 54 cells/mm³.
Three of the five confirmed PML cases died; the time between diagnosis and death was 2, 5, and 6 months. It is important to consider JCV infection as a differential diagnosis.
进行性多灶性白质脑病（PML）是一种由 JC 病毒（JCV）激活引起的中枢神经系统脱髓鞘疾病。
我们描述了 AIDS 患者中经实验室确诊的 PML 病例的特征。
共获得 43 例 HIV 患者，其临床状况与 PML 相符，其中 5 例通过 JCV 检测得到确诊。主要的临床发现是精神错乱。中位 CD4 计数为 54 个细胞/mm³。
5 例确诊的 PML 病例中有 3 例死亡；从诊断到死亡的时间分别为 2、5 和 6 个月。考虑 JCV 感染作为鉴别诊断非常重要。
