Universidad Autónoma de Bucaramanga, Faculty of Health Sciences, Bucaramanga, Santander, Colombia.
Clínica FOSCAL, Hematopoietic and Stem Cell Transplantation Unit, Floridablanca, Santander, Colombia.
Rev Soc Bras Med Trop. 2020 Dec 21;54:e20200143. doi: 10.1590/0037-8682-0143-2020. eCollection 2020.
Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
恰加斯病（CD）是一种由克氏锥虫引起的原生动物人畜共患病。CD 在移植前和移植期间因药物诱导的免疫抑制而重新激活。在这里，我们报告了一例 62 岁男性经典霍奇金淋巴瘤患者，在接受干细胞移植（SCT）前接受了高强度的预处理化疗。该患者在移植前评估中 CD 检测呈阳性。该患者在 SCT 前后持续发热和 C 反应蛋白水平升高，并接受了抗生素治疗。微斯特劳特试验显示有锥虫的存在，他接受了苯并咪唑治疗，直到检测结果转为阴性。移植后血清阳性患者应进行筛查，以确定是否有重新激活的可能。
