Siow Isabel, Lee Keng Siang, Zhang John J Y, Saffari Seyed Ehsan, Ng Adeline, Young Barnaby
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK.
J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105549. doi: 10.1016/j.jstrokecerebrovasdis.2020.105549. Epub 2020 Dec 15.
COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19.
We conducted a systematic review of all studies published between November 1, 2019 and July 8, 2020 which reported on patients who suffered from stroke as a complication of COVID-19.
326 studies were screened, and 30 studies reporting findings from 55,176 patients including 899 with stroke were included. The average age of patients who suffered from stroke as a complication of COVID-19 was 65.5 (Range: 40.4-76.4 years). The average incidence of stroke as a complication of COVID-19 was 1.74% (95% CI: 1.09% to 2.51%). The average mortality of stroke in COVID-19 patients was 31.76% (95% CI: 17.77% to 47.31%). These patients also had deranged clinical parameters including deranged coagulation profiles, liver function tests, and full blood counts.
Although stroke is an uncommon complication of COVID-19, when present, it often results in significant morbidity and mortality. In COVID-19 patients, stroke was associated with older age, comorbidities, and severe illness.
新型冠状病毒肺炎（COVID-19）是一种多系统感染性疾病，主要影响呼吸系统，但也会引发全身炎症、血管内皮炎症和血栓形成。其后果包括肾功能障碍、肝炎和中风。在本系统评价中，我们旨在评估作为COVID-19并发症的中风患者的流行病学、临床病程及转归。
我们对2019年11月1日至2020年7月8日期间发表的所有报告COVID-19并发症中风患者情况的研究进行了系统评价。
共筛选了326项研究，纳入了30项报告55176例患者研究结果的研究，其中包括899例中风患者。作为COVID-19并发症的中风患者平均年龄为65.5岁（范围：40.4 - 76.4岁）。COVID-19并发症中风的平均发病率为1.74%（95%置信区间：1.09%至2.51%）。COVID-19患者中风的平均死亡率为31.76%（95%置信区间：17.77%至47.31%）。这些患者还存在临床指标紊乱，包括凝血指标、肝功能检查和全血细胞计数异常。
虽然中风是COVID-19的一种罕见并发症，但一旦发生，往往会导致显著的发病率和死亡率。在COVID-19患者中，中风与高龄、合并症和重症相关。
