Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran; Neurosurgery Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran.
J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105552. doi: 10.1016/j.jstrokecerebrovasdis.2020.105552. Epub 2020 Dec 17.
Coronavirus disease 2019 (COVID-19) is primarily known as a respiratory illness; however, a wide variety of symptoms and complications of the central nervous system (CNS), such as ischemic cerebrovascular accidents (CVA) have been reported. Hereby, we provide a systematic review and a meta-analysis of the literature, investigating the incidence of ischemic CVA and the mortality due to it in the setting of COVID-19.
Our search databases included Google Scholar, MEDLINE via PubMed, and Scopus. We searched the databases up to July 22, 2020. The primary outcome was the incidence of ischemic CVA in COVID-19 cases, while the secondary outcomes were the ratio of mortality in these cases. Standard meta-analysis methods used to measure the pooled incidence and mortality rates of ischemic CVA in COVID-19 cases.
After excluding studies with reasons, only 20 articles were eligible to be included in our qualitative synthesis, and 17 studies were evaluated quantitatively in our meta-analysis. Included studies reported a pooled average incidence of 1.7% for ischemic CVA, ranging from 1.3% to 2.3%. Mortality in patients of ischemic CVA to all COVID-19 cases was 0.5%, ranging from 0.4% to 0.6%. The mortality rate of patients with CVA to those who suffered from COVID-19 infection and ischemic CVA simultaneously was 29.2% ranging from 21.6% to 38.2%. Overall, the heterogeneity of the studies was high.
Our analysis revealed a pooled incidence of 1.7% for ischemic CVA in the setting of COVID-19 infection, with a mortality rate of 29.2% amongst the COVID-19 patients who are suffering ischemic CVA.
新型冠状病毒病（COVID-19）主要被认为是一种呼吸道疾病；然而，据报道，中枢神经系统（CNS）出现了各种各样的症状和并发症，如缺血性脑血管意外（CVA）。在此，我们对 COVID-19 背景下缺血性 CVA 的发病率及其导致的死亡率进行了系统评价和荟萃分析。
我们的检索数据库包括 Google Scholar、PubMed 中的 MEDLINE 和 Scopus。我们的检索截至 2020 年 7 月 22 日。主要结局是 COVID-19 病例中缺血性 CVA 的发生率，次要结局是这些病例的死亡率。标准荟萃分析方法用于测量 COVID-19 病例中缺血性 CVA 的汇总发生率和死亡率。
排除有原因的研究后，只有 20 篇文章有资格进行定性综合分析，17 篇研究在荟萃分析中进行了定量评估。纳入的研究报告缺血性 CVA 的总体平均发生率为 1.7%，范围为 1.3%至 2.3%。缺血性 CVA 患者在所有 COVID-19 病例中的死亡率为 0.5%，范围为 0.4%至 0.6%。同时患有 COVID-19 感染和缺血性 CVA 的患者中 CVA 患者的死亡率为 29.2%，范围为 21.6%至 38.2%。总体而言，研究的异质性很高。
我们的分析显示，COVID-19 感染患者中缺血性 CVA 的总体发生率为 1.7%，同时患有 COVID-19 感染和缺血性 CVA 的患者中 CVA 患者的死亡率为 29.2%。
