Artificial Intelligence in Medical Imaging Laboratory, ARTORG Center for, Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Department of Ophthalmology, University Hospital Bern, University of Bern, Bern, Switzerland.
Transl Vis Sci Technol. 2020 Dec 2;9(13):3. doi: 10.1167/tvst.9.13.3. eCollection 2020 Dec.
To clinically validate the noninferiority of the sequentially optimized reconstruction strategy (SORS) when compared to the dynamic strategy (DS).
SORS is a novel perimetry testing strategy that evaluates a subset of test locations of a visual field (VF) test pattern and estimates the untested locations by linear approximation. When testing fewer locations, SORS has been shown in computer simulations to bring improvements in speed over conventional perimetry tests, while maintaining acquisition at high-quality acquisition. To validate SORS, a prospective clinical study was conducted at the Department of Ophthalmology of Bern University Hospital, over 12 months. Eighty-three subjects (32 healthy and 51 glaucoma patients with early to moderate visual field loss) of 114 participants were included in the study. The subjects underwent perimetry tests on an Octopus 900 (Haag-Streit, Köniz, Switzerland) using the G pattern with both DS and SORS. The acquired sensitivity thresholds (ST) by both tests were analyzed and compared.
DS-acquired VFs were used as a reference. High correlations between individual STs ( ≥ 074), as well as between mean defect values ( ≥ 088) given by DS and SORS were obtained. The mean absolute error of SORS was under 3 dB with a 70% reduction in acquisition time. SORS overestimated healthy VFs while slightly underestimating glaucomatous VFs. Qualitatively, SORS acquisition yielded VF with detectable defect patterns, albeit some isolated and small defects were occasionally missed.
This clinical study showed that for healthy and glaucomatous patients, SORS-acquired VFs sufficiently correlated with the DS-acquired VFs with up to 70% reduction in acquisition time.
This clinical study suggests that the novel perimetry strategy SORS could be used in routine clinical practice with comparable utility to the current standard DS, whereby providing a shorter and more comfortable perimetry experience.
临床验证序贯优化重建策略（SORS）与动态策略（DS）相比的非劣效性。
SORS 是一种新的视野（VF）测试策略，它评估视野测试模式的一小部分测试位置，并通过线性逼近估计未测试的位置。在测试较少的位置时，计算机模拟显示 SORS 可提高速度，优于传统的视野测试，同时保持高质量的采集。为了验证 SORS，在伯尔尼大学医院眼科进行了一项前瞻性临床研究，历时 12 个月。该研究共纳入了 114 名参与者中的 83 名受试者（32 名健康受试者和 51 名早期至中度视野丧失的青光眼患者）。受试者使用 Haag-Streit（瑞士 Köniz）的 Octopus 900 进行了 G 型 DS 和 SORS 的视野测试。分析和比较了两种测试获得的灵敏度阈值（ST）。
DS 获得的 VF 用作参考。DS 和 SORS 获得的个体 ST（≥074）以及平均缺损值（≥088）之间存在高度相关性。SORS 的平均绝对误差小于 3dB，采集时间减少了 70%。SORS 高估了健康的 VF，而略低估了青光眼的 VF。定性上，SORS 采集的 VF 具有可检测的缺陷模式，尽管偶尔会错过一些孤立的小缺陷。
这项临床研究表明，对于健康和青光眼患者，SORS 获得的 VF 与 DS 获得的 VF 具有高度相关性，采集时间减少了 70%。
许梦洁
