Sarangi Sujata, Khera Sudeep, Vishwajeet Vikarn, Meshram Vikas, Setia Puneet, Malik Abhishek
All India Institute of Medical Sciences, Department of Pathology & Laboratory Medicine, Jodhpur, Rajasthan.
All India Institute of Medical Sciences, Department of Forensic Medicine and Toxicology, Jodhpur, Rajasthan.
Autops Case Rep. 2020 Nov 20;10(4):e2020222. doi: 10.4322/acr.2020.222.
Sinonasal Undifferentiated carcinoma (SNUC) comprises 3% of the head and neck tumors, including metastatic neoplasms. Herein we report the case of a 60-year-old male who was brought dead to our institute with previous records of a contrast-enhanced CT scan of the brain and MRI with evidence of tumor in the maxillary sinus with intracranial extensions. The histopathological examination of the mass in the maxillary sinus proved to be SNUC with metastases to the brain, lungs, and around the aorta. These tumors are undifferentiated and are distinct from other poorly differentiated tumors in deriving their origin from the Schneiderian epithelium. The aggressive nature of the tumor renders the prognosis quite dismal. SNUCs need to be early recognized and distinguished from other poorly differentiated carcinomas with the help of immunohistochemistry.
鼻窦未分化癌(SNUC)占头颈肿瘤的3%,包括转移性肿瘤。在此,我们报告一例60岁男性病例,该患者被送至我院时已死亡,之前有脑部增强CT扫描和MRI记录,显示上颌窦有肿瘤并伴有颅内扩展。上颌窦肿物的组织病理学检查证实为SNUC,已转移至脑、肺和主动脉周围。这些肿瘤未分化,与其他低分化肿瘤不同,其起源于施奈德上皮。肿瘤的侵袭性导致预后相当不佳。SNUC需要借助免疫组织化学尽早识别并与其他低分化癌相区分。