Berkovic Maja Cigrovski, Cigrovski Vjekoslav, Bilic-Curcic Ines, Mrzljak Anna
Department for Endocrinology, Diabetes and Metabolism, Clinical Hospital Dubrava, Zagreb 10000, Croatia.
Faculty of Kinesiology, University of Zagreb, Zagreb 10000, Croatia.
World J Clin Cases. 2020 Dec 6;8(23):5844-5851. doi: 10.12998/wjcc.v8.i23.5844.
In the last decades, more efforts are focused on the prevention and treatment of malignant diseases, given the increase in all cancers incidence A lifestyle change, including healthy eating habits and regular physical activity, has significantly impacted colorectal cancer prevention. The effect of dose-dependent physical activity on mortality and recurrence rates of colorectal carcinoma has been unequivocally demonstrated in observational studies. However, clear recommendations are not available on the frequency, duration, and intensity of exercise in patients with colorectal cancer due to the lack of evidence in randomized clinical trials. Regarding pathophysiological mechanisms, the most plausible explanation appears to be the influence of physical activity on reducing chronic inflammation and insulin resistance with a consequent positive effect on insulin growth factor 1 signaling pathways.
在过去几十年中，鉴于所有癌症发病率的上升，更多的努力集中在恶性疾病的预防和治疗上。生活方式的改变，包括健康的饮食习惯和定期的体育活动，对结直肠癌的预防产生了显著影响。观察性研究已明确证实剂量依赖性体育活动对结直肠癌死亡率和复发率的影响。然而，由于缺乏随机临床试验的证据，对于结直肠癌患者运动的频率、持续时间和强度尚无明确建议。关于病理生理机制，最合理的解释似乎是体育活动对减轻慢性炎症和胰岛素抵抗的影响，从而对胰岛素生长因子1信号通路产生积极作用。
