Fleischmann Chen, Horowitz Michal, Yanovich Ran, Raz Hany, Heled Yuval
Institute of Military Physiology, IDF Medical Corps, Tel-Hashomer, Israel.
Heller Institute of Medical Research, Sheba Medical Center, Ramat Gan, Israel.
Front Sports Act Living. 2019 Sep 4;1:17. doi: 10.3389/fspor.2019.00017. eCollection 2019.
To examine the supplementation effects of the xanthophyll carotenoid Astaxanthin on physical performance and exertional heat strain in humans. A randomized double blind placebo controlled trial. Twenty two male participants (Age: 23.14 ± 3.5 y, height: 175 ± 6 cm, body mass: 69.6 ± 8.7 kg, % body fat: 16.8 ± 3.8) received placebo (PLA, = 10) or Astaxanthin (ATX, = 12) 12 mg/day Per os (P.O), for 30 days, and were tested pre and post-supplementation with a maximal oxygen uptake (VO Max) test and the heat tolerance test (HTT) (2 h walk at 40°C, 40% relative humidity (RH), 5 kph, 2% incline). NIH database registration no. NCT02088242. Gas exchange, Heart rate (HR), Relative perceived exertion (RPE), and blood lactate were measured during the VO Max test. Heart rate (HR), rectal (Trec), and skin (Tskin) temperatures, RPE, and sweat rate (SR) were monitored in the HTT. Serum heat shock protein 72 (HSP72), Creatine phospho-kinase (CPK), C-reactive protein (CRP), and lipid profile were measured before and after the test. The rise in blood lactate caused by the VO Max test was significantly diminished in the ATX group (9.4 ± 3.1 and 13.0 ± 3.1 mmolel in the ATX and PLA groups, respectively < 0.02), as was the change in oxygen uptake during recovery (-2.02 ± 0.64 and 0.83 ± 0.79% of VO Max in the ATX and PLA group, respectively, = 0.001). No significant differences were observed in the anaerobic threshold or VO Max. In the HTT, no significant physiological or biochemical differences were observed (HR <120 bpm, Trec rose by ~1°C to <38°C, no difference in SR). Astaxanthin supplementation improved exercise recovery. No benefit was observed for ATX over PLA in response to heat stress. Further examination of Astaxanthin in higher exertional heat strain is required.
为研究叶黄素类胡萝卜素虾青素对人体体能及运动热应激的补充效果。进行一项随机双盲安慰剂对照试验。22名男性参与者（年龄：23.14±3.5岁，身高：175±6厘米，体重：69.6±8.7千克，体脂百分比：16.8±3.8）口服接受安慰剂（PLA，n = 10）或虾青素（ATX，n = 12），剂量为每日12毫克，持续30天，并在补充前后分别进行最大摄氧量（VO₂Max）测试和耐热性测试（HTT）（在40℃、相对湿度40%（RH）、速度5千米/小时、坡度2%的条件下步行2小时）。美国国立医学图书馆数据库注册号：NCT02088242。在VO₂Max测试期间测量气体交换、心率（HR）、主观用力程度（RPE）和血乳酸。在HTT中监测心率（HR）、直肠温度（Trec）、皮肤温度（Tskin）、RPE和出汗率（SR）。在测试前后测量血清热休克蛋白72（HSP72）、肌酸磷酸激酶（CPK）、C反应蛋白（CRP）和血脂谱。VO₂Max测试引起的血乳酸升高在ATX组显著降低（ATX组和PLA组分别为9.4±3.1和13.0±3.1毫摩尔/升，P<0.02），恢复期间的摄氧量变化也是如此（ATX组和PLA组分别为VO₂Max的-2.02±0.64%和0.83±0.79%，P = 0.001）。在无氧阈值或VO₂Max方面未观察到显著差异。在HTT中，未观察到显著的生理或生化差异（HR<120次/分钟，Trec升高约1℃至<38℃，SR无差异）。补充虾青素可改善运动恢复。在应对热应激方面，未观察到ATX比PLA有优势。需要进一步研究虾青素在更高运动热应激情况下的作用。
