非编码 RNA 在肥胖中的表达谱及作用。
The expression profile and role of non-coding RNAs in obesity.
机构信息
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Eur J Pharmacol. 2021 Feb 5;892:173809. doi: 10.1016/j.ejphar.2020.173809. Epub 2020 Dec 17.
Latest years have experienced a dramatic upsurge in the knowledge about the function of non-coding transcripts in the determination of diverse human phenotypes including obesity. Several miRNAs and lncRNAs participate in the regulation of metabolic pathways leading to obesity. Several lncRNAs such as Mist, lincIRS2, lncRNA-p5549, H19, GAS5 and SNHG9 have been shown to be down-regulated in adipose tissues or other biological samples in the obese human or animal subjects. On the other hand, Meg3, Plnc1, Blnc1, AC092834.1, TINCR and PVT1 are among up-regulated lncRNAs in the obese subjects. Tens of miRNAs have differential expression between obese and non-obese subjects or between mature adipocytes and pre-adipocytes. Understanding the molecular mechanism of involvement of non-coding RNAs in the pathobiology of obesity would simplify design of therapeutic choices for protecting against obesity and its related comorbidities. We explain the available literature on the function of these transcripts in the pathobiology of obesity.
近年来，人们对非编码转录物在决定包括肥胖在内的多种人类表型中的功能有了深刻的认识。几种 miRNA 和 lncRNA 参与了代谢途径的调节，导致肥胖。几种 lncRNA，如 Mist、lincIRS2、lncRNA-p5549、H19、GAS5 和 SNHG9，已被证明在肥胖人群或动物的脂肪组织或其他生物样本中下调。另一方面，Meg3、Plnc1、Blnc1、AC092834.1、TINCR 和 PVT1 是肥胖人群中上调的 lncRNA 之一。数十种 miRNA 在肥胖和非肥胖个体之间或成熟脂肪细胞和前脂肪细胞之间存在差异表达。了解非编码 RNA 参与肥胖症病理生物学的分子机制将简化针对肥胖及其相关合并症的保护的治疗选择设计。我们解释了这些转录物在肥胖症病理生物学中的功能的现有文献。
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