Meng Xiao, Li Ya, Li Sha, Gan Ren-You, Li Hua-Bin
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Dept. of Nutrition, School of Public Health, Sun Yat-sen Univ., Guangzhou 510080, China.
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The Univ. of Hong Kong, Hong Kong, China.
Compr Rev Food Sci Food Saf. 2018 Mar;17(2):472-495. doi: 10.1111/1541-4337.12335. Epub 2018 Feb 7.
Chemicals (such as alcohol, drugs, and pollutants) may cause liver injuries, which could consequently develop into fatty liver, hepatitis, fibrosis, cirrhosis, and liver failure, or even cancers. Liver injuries have been a serious public health problem worldwide. Numerous natural products and their bioactive components have shown protective action for liver injuries, such as blueberry, cactus fruits, Pueraria lobate, betaine, and silymarin. The underlying mechanisms mainly include antioxidation, anti-inflammation, anti-apoptosis, anti-necrosis, repairing damaged DNA, regulating the metabolism of lipids, and modulating primary bile acid biosynthesis. This review summarizes the natural products and bioactive compounds with protective effects on liver injuries caused by chemicals, and special attention is paid to the mechanisms of action. This updated information can be helpful to prevent and treat liver-related diseases, especially chemical-induced liver injuries.
化学物质（如酒精、药物和污染物）可能会导致肝损伤，进而发展为脂肪肝、肝炎、肝纤维化、肝硬化和肝衰竭，甚至癌症。肝损伤已成为全球严重的公共卫生问题。许多天然产物及其生物活性成分已显示出对肝损伤的保护作用，如蓝莓、仙人掌果实、葛根、甜菜碱和水飞蓟素。其潜在机制主要包括抗氧化、抗炎、抗凋亡、抗坏死、修复受损DNA、调节脂质代谢以及调节初级胆汁酸生物合成。本综述总结了对化学物质引起的肝损伤具有保护作用的天然产物和生物活性化合物，并特别关注其作用机制。这些更新的信息有助于预防和治疗肝脏相关疾病，尤其是化学物质诱导的肝损伤。
