Cardiovascular Risk, Nutrition and Aging Research Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain.
Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
Nutrients. 2020 Dec 19;12(12):3895. doi: 10.3390/nu12123895.
Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; = 6772); (2) acetylsalicylic acid as antiplatelet agent ( = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46-0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HR: 4.22 [1.92-9.30], HR: 1.71 [0.83-3.52], -interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.
我们旨在评估遵循地中海饮食（MedDiet）是否会降低高心血管风险的老年人开始抗血栓治疗的风险以及与该治疗相关的心血管风险。我们评估了（PREDIMED）研究中的参与者，他们被分配到富含特级初榨橄榄油或坚果的 MedDiet（与低脂肪对照干预相比），是否在开始使用：（1）维生素 K 环氧化物还原酶抑制剂（醋硝香豆素/华法林； = 6772）；（2）作为抗血小板药物的乙酰水杨酸（ = 5662）；和（3）其他抗血小板药物（西洛他唑/氯吡格雷/双嘧达莫/地尔硫卓/噻氯匹定/曲伐他汀； = 6768）方面存在差异。我们还评估了 MedDiet 是否改变了抗血栓药物基线使用与新发心血管事件之间的关联。与对照饮食相比，富含特级初榨橄榄油的 MedDiet 干预降低了使用维生素 K 环氧化物还原酶抑制剂的风险（HR：0.68 [0.46-0.998]）。对于未接受 MedDiet 干预的参与者，他们的使用与心血管疾病风险增加的相关性更强（HR：4.22 [1.92-9.30]，HR：1.71 [0.83-3.52]，-交互作用= 0.052）。总之，在高心血管风险的老年人群中，遵循 MedDiet 可降低抗血栓治疗的启动率以及维生素 K 环氧化物还原酶抑制剂使用者发生主要心血管事件的风险。
