Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.
Molecules. 2020 Dec 18;25(24):6013. doi: 10.3390/molecules25246013.
Generally, biosensors are designed to translate physical, chemical, or biological events into measurable signals, thus offering qualitative and/or quantitative information regarding the target analytes. While the biosensor field has received considerable scientific interest, integrating this technology with microfluidics could further bring significant improvements in terms of sensitivity and specificity, resolution, automation, throughput, reproducibility, reliability, and accuracy. In this manner, biosensors-on-chip (BoC) could represent the bridging gap between diagnostics in central laboratories and diagnostics at the patient bedside, bringing substantial advancements in point-of-care (PoC) diagnostic applications. In this context, the aim of this manuscript is to provide an up-to-date overview of BoC system development and their most recent application towards the diagnosis of cancer, infectious diseases, and neurodegenerative disorders.
通常，生物传感器旨在将物理、化学或生物事件转化为可测量的信号，从而提供有关目标分析物的定性和/或定量信息。虽然生物传感器领域引起了相当大的科学关注，但将该技术与微流控技术相结合，在灵敏度和特异性、分辨率、自动化、通量、重现性、可靠性和准确性方面可以带来显著的改进。通过这种方式，芯片上的生物传感器（BoC）可以弥合中心实验室诊断和患者床边诊断之间的差距，在即时诊断应用中带来实质性的进步。在这种情况下，本文的目的是提供 BoC 系统开发的最新概述及其在癌症、传染病和神经退行性疾病诊断方面的最新应用。
