Jain Akhilesh, Meena Richpal, Sharma Rekha, Yadav Neelam, Mathur Anadi, Jain Garima
Department of Psychiatry, ESIC Model Hospital, Jaipur, Rajasthan, India.
Department of Pulmonary Medicine, ESIC Model Hospital, Jaipur, Rajasthan, India.
Indian J Community Med. 2020 Jul-Sep;45(3):338-342. doi: 10.4103/ijcm.IJCM_376_19. Epub 2020 Sep 1.
Chronic diseases such as chronic obstructive pulmonary disease (COPD) have an adverse impact on the quality of life (QOL) of the patient. Anxiety and depression have an association with QOL in COPD. However, this area has not been studied in the Indian subcontinent, especially in reference to the industrial population, which is vulnerable to such chronic disease. The present study aims to assess the prevalence of anxiety and depression and its association with QOL in COPD patients. This study has also examined the other predictive factors associated with QOL in COPD.
This cross-sectional study involved 50 cases of COPD and an equal number of age- and sex-matched healthy controls. The severity of COPD was classified as per the global initiative for chronic obstructive lung disease recommendation. Participants were assessed for anxiety, depression, and QOL on generalized anxiety disorder 7, Patient Health Questionnaire nine-item and WHOQOL (World Health Organization Quality of Life Instrument)-BREF, respectively.
The study sample was predominantly of men ( = 47) with a mean age of 57 years. The mean score of QOL in all domains was significantly lower in COPD cases than control. The prevalence of anxiety and depression was 38% and 44%, respectively, among COPD cases. Odds ratios predicted more risk of developing anxiety and depression in COPD as the OR for depression and anxiety, with 95% confidence intervals were 3.2 (1.2-8.3 and 4.8 (1.8-12.8), respectively. QOL had a strong association with anxiety, depression, chronicity, and the severity of the disease.
Anxiety and depression are highly prevalent in COPD and appear to be strong predictors of poor QOL.
慢性阻塞性肺疾病（COPD）等慢性病会对患者的生活质量（QOL）产生不利影响。焦虑和抑郁与COPD患者的生活质量相关。然而，在印度次大陆尚未对该领域进行研究，尤其是针对易患此类慢性病的产业工人人群。本研究旨在评估COPD患者焦虑和抑郁的患病率及其与生活质量的关系。本研究还探讨了与COPD患者生活质量相关的其他预测因素。
本横断面研究纳入了50例COPD患者以及数量相等的年龄和性别匹配的健康对照。根据慢性阻塞性肺疾病全球倡议的建议对COPD的严重程度进行分类。分别使用广泛性焦虑障碍7项量表、患者健康问卷9项量表和世界卫生组织生活质量量表简表（WHOQOL-BREF）对参与者的焦虑、抑郁和生活质量进行评估。
研究样本以男性为主（n = 47），平均年龄为57岁。COPD患者所有领域的生活质量平均得分均显著低于对照组。COPD患者中焦虑和抑郁的患病率分别为38%和44%。抑郁和焦虑的比值比预测COPD患者发生焦虑和抑郁的风险更高，95%置信区间分别为3.2（1.2 - 8.3）和4.8（1.8 - 12.8）。生活质量与焦虑、抑郁、病程和疾病严重程度密切相关。
焦虑和抑郁在COPD患者中高度流行，似乎是生活质量差的有力预测因素。
