玻璃酸钠浓度对泪膜新月形高度的影响：单次滴眼后 10 分钟动态曲线。

Influence of Sodium Hyaluronate Concentration in Tear Meniscus Height: 10-min Dynamic Profile After Single Instillation.

机构信息

Department of Ophthalmology (C.R.-L., J.T.-S., J.P.-N.), Hospital Clinic de Barcelona Institut Clinic d'Oftalmologia, Barcelona, Spain; Department of Physics of Condensed Matter (J.-M.S.-G.), Optics Area, University of Seville, Seville, Spain; Department of Ophthalmology (J.-M.S.-G.), Tecnolaser Clinic Vision, Refractive Surgery Centre, Seville, Spain; and Department of Ophthalmology (F.Z.-M., R.R.-A.), Regional Universitary Hospital of Malaga, Malaga, Spain.

出版信息

Eye Contact Lens. 2021 Jun 1;47(6):330-334. doi: 10.1097/ICL.0000000000000733.

DOI:10.1097/ICL.0000000000000733

PMID:33355428

Abstract

PURPOSE

To assess the height, area, and density of tear meniscus throughout 10 min after instillation of sodium hyaluronate (SH) of equal molecular weight at two different concentrations.

METHODS

Thirty-four eyes from 17 patients were enrolled in this longitudinal, nonrandomized, interventional and contralateral eye study. Tear meniscus height (TMH), corneal meniscus junction (CMJ), lower-lid meniscus junction (LLMJ), and tear meniscus area (TMA) images were obtained with the anterior segment module of the deep range imaging ocular coherence tomography ([DRI-OCT] Triton Swept-Source). Tear meniscus density (TMD) was calculated using the image processing and analysis software by Java (ImageJ program). Sodium hyaluronate artificial tears at 0.1% and 0.2% concentrations were instilled into all right and left eyes, respectively.

RESULTS

Patients' mean age was 61.05±11.43 years. Tear meniscus height, CMJ, LLMJ, and TMA measured at 1-, 5-, 7- and 10-min postinstillation of 0.1% SH proved significant differences among them (P<0.05). Sodium hyaluronate 0.2% instillation obtained similar findings, although no significant differences were found between 1- and 3-min postinstillation measurements (P>0.05). Fewer differences were found in TMD 0.2% SH group due to a lower baseline densitometry compared to the 0.1% group.

CONCLUSION

0.2% sodium hyaluronate achieved better TMH and TMA in 1 and 3 min after instillation than 0.1% concentration. However, there were no statistically significant differences between 0.1% and 0.2% sodium hyaluronate throughout a ten-minute longitudinal profile measurement using DRI-OCT.

摘要

目的

评估两种不同浓度的等分子量透明质酸钠（SH）滴注后 10 分钟内泪膜新月高度、面积和密度的变化。

方法

本研究为一项纵向、非随机、干预性和对侧眼研究，纳入了 17 名患者的 34 只眼。使用深度成像眼前节光学相干断层扫描（DRI-OCT）[Triton 扫频源]的前段模块获取泪膜新月高度（TMH）、角膜新月交接（CMJ）、下睑新月交接（LLMJ）和泪膜新月面积（TMA）图像。使用 Java（ImageJ 程序）图像处理和分析软件计算泪膜新月密度（TMD）。分别将 0.1%和 0.2%浓度的透明质酸钠人工泪液滴入所有右眼和左眼。

结果

患者的平均年龄为 61.05±11.43 岁。0.1%SH 滴注后 1、5、7 和 10 分钟测量的 TMH、CMJ、LLMJ 和 TMA 均有显著差异（P<0.05）。0.2%SH 滴注也得到了类似的结果，尽管在 1 和 3 分钟的滴注后测量中没有发现显著差异（P>0.05）。与 0.1%SH 组相比，0.2%SH 组的 TMD 较低，因此差异较小。