Department of Ophthalmology (C.R.-L., J.T.-S., J.P.-N.), Hospital Clinic de Barcelona Institut Clinic d'Oftalmologia, Barcelona, Spain; Department of Physics of Condensed Matter (J.-M.S.-G.), Optics Area, University of Seville, Seville, Spain; Department of Ophthalmology (J.-M.S.-G.), Tecnolaser Clinic Vision, Refractive Surgery Centre, Seville, Spain; and Department of Ophthalmology (F.Z.-M., R.R.-A.), Regional Universitary Hospital of Malaga, Malaga, Spain.
Eye Contact Lens. 2021 Jun 1;47(6):330-334. doi: 10.1097/ICL.0000000000000733.
To assess the height, area, and density of tear meniscus throughout 10 min after instillation of sodium hyaluronate (SH) of equal molecular weight at two different concentrations.
Thirty-four eyes from 17 patients were enrolled in this longitudinal, nonrandomized, interventional and contralateral eye study. Tear meniscus height (TMH), corneal meniscus junction (CMJ), lower-lid meniscus junction (LLMJ), and tear meniscus area (TMA) images were obtained with the anterior segment module of the deep range imaging ocular coherence tomography ([DRI-OCT] Triton Swept-Source). Tear meniscus density (TMD) was calculated using the image processing and analysis software by Java (ImageJ program). Sodium hyaluronate artificial tears at 0.1% and 0.2% concentrations were instilled into all right and left eyes, respectively.
Patients' mean age was 61.05±11.43 years. Tear meniscus height, CMJ, LLMJ, and TMA measured at 1-, 5-, 7- and 10-min postinstillation of 0.1% SH proved significant differences among them (P<0.05). Sodium hyaluronate 0.2% instillation obtained similar findings, although no significant differences were found between 1- and 3-min postinstillation measurements (P>0.05). Fewer differences were found in TMD 0.2% SH group due to a lower baseline densitometry compared to the 0.1% group.
0.2% sodium hyaluronate achieved better TMH and TMA in 1 and 3 min after instillation than 0.1% concentration. However, there were no statistically significant differences between 0.1% and 0.2% sodium hyaluronate throughout a ten-minute longitudinal profile measurement using DRI-OCT.
评估两种不同浓度的等分子量透明质酸钠（SH）滴注后 10 分钟内泪膜新月高度、面积和密度的变化。
本研究为一项纵向、非随机、干预性和对侧眼研究，纳入了 17 名患者的 34 只眼。使用深度成像眼前节光学相干断层扫描（DRI-OCT）[Triton 扫频源]的前段模块获取泪膜新月高度（TMH）、角膜新月交接（CMJ）、下睑新月交接（LLMJ）和泪膜新月面积（TMA）图像。使用 Java（ImageJ 程序）图像处理和分析软件计算泪膜新月密度（TMD）。分别将 0.1%和 0.2%浓度的透明质酸钠人工泪液滴入所有右眼和左眼。
患者的平均年龄为 61.05±11.43 岁。0.1%SH 滴注后 1、5、7 和 10 分钟测量的 TMH、CMJ、LLMJ 和 TMA 均有显著差异（P<0.05）。0.2%SH 滴注也得到了类似的结果，尽管在 1 和 3 分钟的滴注后测量中没有发现显著差异（P>0.05）。与 0.1%SH 组相比，0.2%SH 组的 TMD 较低，因此差异较小。
0.2%SH 在滴注后 1 分钟和 3 分钟时的 TMH 和 TMA 均优于 0.1%浓度，但在 DRI-OCT 进行的长达 10 分钟的纵向测量中，0.1%和 0.2%SH 之间没有统计学上的显著差异。
