Department of Medical Diagnostics Technologies and Rehabilitation, Oles Honchar Dnipro National University, Dnipro 49000, Ukraine.
Pathology and Cytology Center, LSI Medience Corporation, Tokyo 174-0051, Japan.
Exp Oncol. 2020 Dec;42(4):314-317. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15437.
Patients with esophageal squamous cell carcinoma (SCC) have a poor prognosis mostly due to the late diagnosis. A morphological method is still the main diagnostic method for SCC. The aim of the study was to find out which histological criteria, namely Western or Japanese criteria, for early stage SCC are used by pathologists in Ukraine as compared with their Japanese colleagues.
14 Ukrainian and 6 Japanese pathologists have participated in this study. Virtual slides for research were provided by National Cancer Research Center (Tokyo, Japan) in 2018. Each of the pathologists has used these slides and presented the conclusion via the Internet.
Essential diagnostic discrepancies were revealed: a number of biopsy specimens was diagnosed by Japanese pathologists as "noninvasive carcinoma", while Ukrainian pathologists classified the specimens as high-grade or low-grade dysplasia, indefinite for neoplasia, or reactive/regenerative lesions.
The adoption of a unified concept of criteria for non-invasive (intraepithelial) carcinoma underlies early endoscopic/surgical treatment, which significantly increases the survival rate of patients with SCC. A solid common approach to the diagnosis between Western and Japanese pathologists, as well as endoscopists, is necessary to ensure timely treatment and increase survival rate of patients with SCC.
食管鳞状细胞癌（SCC）患者的预后较差，主要原因是诊断较晚。形态学方法仍然是 SCC 的主要诊断方法。本研究的目的是找出乌克兰病理学家与日本同行相比，使用哪些组织学标准（即西方或日本标准）来诊断早期 SCC。
本研究共有 14 名乌克兰和 6 名日本病理学家参与。2018 年，国家癌症研究中心（日本东京）提供了用于研究的虚拟幻灯片。每位病理学家都使用这些幻灯片，并通过互联网提交结论。
发现了一些基本的诊断差异：一些活检标本被日本病理学家诊断为“非浸润性癌”，而乌克兰病理学家则将这些标本归类为高级或低级上皮内瘤变、不确定为肿瘤、反应性/再生性病变。
采用统一的非浸润性（上皮内）癌标准概念是早期内镜/手术治疗的基础，这显著提高了 SCC 患者的生存率。西方和日本病理学家以及内镜医生之间需要建立坚实的共同诊断方法，以确保及时治疗并提高 SCC 患者的生存率。
