Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
Wellcome Trust Centre for Neuroimaging, University College London, London, UK; Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
Neuron. 2021 Mar 3;109(5):882-893.e7. doi: 10.1016/j.neuron.2020.12.007. Epub 2020 Dec 23.
Our brains at rest spontaneously replay recently acquired information, but how this process is orchestrated to avoid interference with ongoing cognition is an open question. Here we investigated whether replay coincided with spontaneous patterns of whole-brain activity. We found, in two separate datasets, that replay sequences were packaged into transient bursts occurring selectively during activation of the default mode network (DMN) and parietal alpha networks. These networks are believed to support inwardly oriented attention and inhibit bottom-up sensory processing and were characterized by widespread synchronized oscillations coupled to increases in high frequency power, mechanisms thought to coordinate information flow between disparate cortical areas. Our data reveal a tight correspondence between two widely studied phenomena in neural physiology and suggest that the DMN may coordinate replay bursts in a manner that minimizes interference with ongoing cognition.
我们的大脑在休息时会自发地重放最近获得的信息，但这个过程是如何组织的，以避免与正在进行的认知产生干扰，这是一个悬而未决的问题。在这里，我们研究了重放是否与全脑活动的自发模式同时发生。我们在两个独立的数据集发现，重放序列被打包成短暂的爆发，选择性地发生在默认模式网络（DMN）和顶叶阿尔法网络的激活期间。这些网络被认为支持内向注意力，并抑制自上而下的感觉处理，其特征是与高频功率增加相关的广泛同步振荡，这些机制被认为协调了不同皮质区域之间的信息流。我们的数据揭示了神经生理学中两个广泛研究的现象之间的紧密对应关系，并表明 DMN 可能以一种最小化与正在进行的认知干扰的方式协调重放爆发。
