Active Pharmaceutical Ingredients Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran.
Carbohydr Polym. 2021 Feb 15;254:117262. doi: 10.1016/j.carbpol.2020.117262. Epub 2020 Oct 23.
A novel theranostic nanoplatform was prepared based on FeO nanoparticles (NPs) coated with gadolinium ions decorated-polycyclodextrin (PCD) layer (FeO@PCD-Gd) and employed for Curcumin (CUR) loading. The dissolution profile of CUR indicated a pH sensitive release manner. FeO@PCD-Gd NPs exhibited no significant toxicity against both normal and cancerous cell lines (MCF 10A and 4T1, respectively); while the CUR-free NPs showed more toxicity against 4T1 than MCF 10A cells. In vivo anticancer study revealed appropriate capability of the system in tumor shrinking with no tissue toxicity and adverse effect on body weight. In vivo MR imaging of BALB/c mouse showed both T and T contrast enhancement on the tumor cells. FeO@PCD-Gd/CUR NPs showed significant features as a promising multifunctional system having appropriate T-T dual contrast enhancement and therapeutic efficacy in cancer theranostics.
一种新型的治疗诊断纳米平台是基于被镝离子修饰的聚环糊精（PCD）层包裹的FeO 纳米粒子（NPs）（FeO@PCD-Gd）而制备的，并用于负载姜黄素（CUR）。CUR 的溶解曲线显示出 pH 敏感的释放方式。FeO@PCD-Gd NPs 对正常和癌细胞系（MCF 10A 和 4T1）均无明显毒性；而无 CUR 的 NPs 对 4T1 细胞的毒性比对 MCF 10A 细胞的毒性更大。体内抗癌研究表明，该系统具有适当的肿瘤缩小能力，对组织无毒性，对体重无不良影响。BALB/c 小鼠的体内磁共振成像显示肿瘤细胞的 T 和 T 对比增强。FeO@PCD-Gd/CUR NPs 表现出作为一种有前途的多功能系统的显著特征，具有适当的 T-T 双重对比增强和癌症治疗诊断的治疗效果。
