Bose Roshnee, Jayawant Maharsh, Raut Rajesh, Lakkakula Jaya, Roy Arpita, Alghamdi Saad, Qusty Naeem F, Sharma Rohit, Verma Devvret, Khandaker Mayeen Uddin, Almujally Abdullah, Tamam Nissren, Sulieman Abdelmoneim
Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai, Maharashtra, India.
Department of Botany, The Institute of Science, Mumbai, Maharashtra, India.
Front Pharmacol. 2023 Aug 3;14:1218867. doi: 10.3389/fphar.2023.1218867. eCollection 2023.
The field of cancer nanotheranostics is rapidly evolving, with cyclodextrin (CD)-based nanoparticles emerging as a promising tool. CDs, serving as nanocarriers, have higher adaptability and demonstrate immense potential in delivering powerful anti-cancer drugs, leading to promising and specific therapeutic outcomes for combating various types of cancer. The unique characteristics of CDs, combined with innovative nanocomplex creation techniques such as encapsulation, enable the development of potential theranostic treatments. The review here focuses mainly on the different techniques administered for effective nanotheranostics applications of CD-associated complex compounds in the domain of cancer treatments. The experimentations on various loaded drugs and their complex conjugates with CDs prove effective in results. Various cancers can have potential nanotheranostics cures using CDs as nanoparticles along with a highly efficient process of nanocomplex development and a drug delivery system. In conclusion, nanotheranostics holds immense potential for targeted drug delivery and improved therapeutic outcomes, offering a promising avenue for revolutionizing cancer treatments through continuous research and innovative approaches.
癌症纳米诊疗领域正在迅速发展，基于环糊精（CD）的纳米颗粒正成为一种很有前景的工具。环糊精作为纳米载体，具有更高的适应性，在递送强效抗癌药物方面显示出巨大潜力，有望为对抗各种类型的癌症带来特异性治疗效果。环糊精的独特特性，与诸如包封等创新的纳米复合物制备技术相结合，能够开发出潜在的诊疗方法。本文综述主要聚焦于在癌症治疗领域中用于环糊精相关复合化合物有效纳米诊疗应用的不同技术。对各种负载药物及其与环糊精的复合缀合物的实验证明结果有效。使用环糊精作为纳米颗粒，以及高效的纳米复合物开发过程和药物递送系统，各种癌症都可能有潜在的纳米诊疗治愈方法。总之，纳米诊疗在靶向药物递送和改善治疗效果方面具有巨大潜力，通过持续研究和创新方法为变革癌症治疗提供了一条充满希望的途径。
