Mufson M A, Belshe R B, Orvell C, Norrby E
Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701.
J Infect Dis. 1988 Jan;157(1):143-8. doi: 10.1093/infdis/157.1.143.
We examined the distribution of subgroups A and B strains from respiratory syncytial virus during five epidemic years from 1981 to 1986 in Huntington, West Virginia. Of 235 infants and children with respiratory syncytial virus infection, 211 had virus reisolated from frozen throat swab specimens for subgroup characterization by reactivity with a panel of monoclonal antibodies to the G, F, NP, M, and P proteins by using an enzyme immunoassay. We identified 160 (75.8%) strains as subgroup A and 51 (24.2%) as subgroup B. Strains of both subgroups were isolated in all years. Small, but approximately equal, numbers of subgroup B strains were isolated each epidemic year. By contrast, subgroup A strains occurred at least three times as often in all years except 1984-1985. The very low number of subgroup A strains isolated during the 1984-1985 epidemic gave dominance to subgroup B strains.
我们研究了1981年至1986年在西弗吉尼亚州亨廷顿的五个流行年份中呼吸道合胞病毒A和B亚组毒株的分布情况。在235例呼吸道合胞病毒感染的婴幼儿中，211例的病毒从冷冻咽拭子标本中重新分离出来，通过酶免疫测定法，利用一组针对G、F、NP、M和P蛋白的单克隆抗体的反应性对亚组进行鉴定。我们鉴定出160株（75.8%）为A亚组毒株，51株（24.2%）为B亚组毒株。两个亚组的毒株在所有年份均有分离。每个流行年份分离出的B亚组毒株数量较少，但大致相等。相比之下，除1984 - 1985年外，A亚组毒株在所有年份出现的频率至少是B亚组的三倍。1984 - 1985年流行期间分离出的A亚组毒株数量极少，使得B亚组毒株占主导地位。
