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比较使用多端口达芬奇 Xi 和 da Vinci SP 机器人进行根治性前列腺切除术的方法:围手术期结局的倾向评分分析。

Comparing the Approach to Radical Prostatectomy Using the Multiport da Vinci Xi and da Vinci SP Robots: A Propensity Score Analysis of Perioperative Outcomes.

机构信息

AdventHealth Global Robotics Institute, Celebration, FL, USA; ORSI Academy, Melle, Belgium.

AdventHealth Global Robotics Institute, Celebration, FL, USA.

出版信息

Eur Urol. 2021 Mar;79(3):393-404. doi: 10.1016/j.eururo.2020.11.042. Epub 2020 Dec 24.

DOI:10.1016/j.eururo.2020.11.042
PMID:33357994
Abstract

BACKGROUND

Use of the single-port da Vinci SP robotic platform for various urological procedures has been described by several groups. However, the comparative performance of the SP robot in relation to earlier models such as the da Vinci Xi is still unclear.

OBJECTIVE

To compare intraoperative and short-term postoperative outcomes between the da Vinci Xi and SP robots for patients undergoing radical prostatectomy (RP) in a referral center.

DESIGN, SETTING, AND PARTICIPANTS: Data were prospectively collected for patients undergoing RP from June 2019 to April 2020 in a single center. The da Vinci SP was used for 71 patients and the da Vinci Xi for 875 patients. After propensity score (PS) matching, two groups of 71 patients were selected for the comparative study.

INTERVENTION

RP via a transperitoneal approach using the same technique steps and anatomy access with both robot consoles.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS

A PS analysis was performed using the covariates age, body mass index, Charlson comorbidity index, Sexual Health Inventory for Men score, American Urological Association symptom score, prostate size, prostate-specific antigen levels, Gleason score, D'Amico risk group, and degree of nerve-sparing. Intraoperative performance and short-term functional (continence and potency) and oncological outcomes were compared between the groups.

RESULTS AND LIMITATIONS

Median follow-up was 4.4 mo (interquartile range [IQR] 1.6-7.2) for the SP group and 3.2 mo (IQR 1.6-4.8) for the Xi group (p =  0.2). The median total operative time and median console time were both significantly higher in the SP group, with median differences of 14 min (95% confidence interval [CI] 9-19) and 5 min (95% CI 0-5), respectively. The proportion of patients with blood loss of >100 ml was significantly lower in the SP group (difference of 27%, 95% CI 12-42%). No intra- or postoperative complications were reported in either group. There were no significant differences in pain scores at 6, 12, and 18 h or in positive surgical margin rates between the groups. The SP group had a significantly higher percentage of extraprostatic extension than the Xi group (difference of 16%, 95% CI 4.6-27%). None of the patients experienced biochemical recurrence during follow-up. The difference in continence rates at 45 d between the SP and Xi groups was 11% (95% CI -5.6% to 28%) and the difference in potency rates at 45 d was -7.3% (95% CI -21% to 6.2%). The short-term follow-up for comparison of functional and oncological outcomes is a limitation.

CONCLUSIONS

Despite differences in trocar placement and technology between the two da Vinci consoles, the SP has satisfactory intraoperative performance compared to the Xi. SP surgery can be performed safely and effectively during the initial learning phase. However, longer-term follow-up is needed to provide further evidence on the impact of SP implementation on functional and oncological outcomes.

PATIENT SUMMARY

We compared intraoperative and short-term postoperative outcomes for patients who underwent radical prostatectomy using two different robots, the da Vinci Xi and the single-port da Vinci SP. We found that operative time was longer for the Single Port console. Studies with long-term follow-up are needed to compare the functional and oncological outcomes.

摘要

背景

已有多个团队描述了单端口达芬奇 SP 机器人平台在各种泌尿科手术中的应用。然而,SP 机器人与早期模型(如达芬奇 Xi)的比较性能仍不清楚。

目的

在一家转诊中心比较接受根治性前列腺切除术(RP)的患者使用达芬奇 Xi 和 SP 机器人的术中及短期术后结果。

设计、地点和参与者:数据是在 2019 年 6 月至 2020 年 4 月期间在一家单中心前瞻性收集的。71 例患者使用达芬奇 SP,875 例患者使用达芬奇 Xi。在进行倾向评分(PS)匹配后,选择两组各 71 例患者进行比较研究。

干预措施

通过经腹途径使用相同的技术步骤和解剖入路进行 RP,两种机器人控制台均可使用。

结局测量和统计分析

使用年龄、体重指数、Charlson 合并症指数、男性健康调查-男性评分、美国泌尿外科学会症状评分、前列腺大小、前列腺特异性抗原水平、Gleason 评分、D'Amico 风险组和神经保留程度作为协变量进行 PS 分析。比较两组之间的术中表现以及短期(控尿和勃起功能)和肿瘤学结局。

结果和局限性

SP 组的中位随访时间为 4.4 个月(四分位距 [IQR] 1.6-7.2),Xi 组为 3.2 个月(IQR 1.6-4.8)(p=0.2)。SP 组的总手术时间和控制台时间中位数均显著较高,分别相差 14 分钟(95%置信区间 [CI] 9-19)和 5 分钟(95%CI 0-5)。SP 组术中出血量>100ml 的患者比例明显较低(差异为 27%,95%CI 12-42%)。两组均无术中或术后并发症报告。两组患者的 6、12 和 18 小时疼痛评分以及阳性切缘率均无显著差异。SP 组的前列腺外延伸比例明显高于 Xi 组(差异为 16%,95%CI 4.6-27%)。在随访期间,无患者发生生化复发。SP 组和 Xi 组的 45 天控尿率差异为 11%(95%CI -5.6%至 28%),45 天勃起功能率差异为-7.3%(95%CI -21%至 6.2%)。比较功能和肿瘤学结局的短期随访是一个局限性。

结论

尽管两种达芬奇控制台的套管放置和技术不同,但 SP 在术中表现与 Xi 相比令人满意。SP 手术可以在初始学习阶段安全有效地进行。然而,需要进行更长时间的随访,以提供关于 SP 实施对功能和肿瘤学结局影响的进一步证据。

患者总结

我们比较了使用两种不同机器人(达芬奇 Xi 和单端口达芬奇 SP)进行根治性前列腺切除术的患者的术中及短期术后结果。我们发现单端口控制台的手术时间更长。需要进行长期随访的研究来比较功能和肿瘤学结果。

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