[125I]Sar1，Ile8 - 血管紧张素II在血液和脑脊液腔室之间移动的无能。

Inability of [125I]Sar1, Ile8-angiotensin II to move between the blood and cerebrospinal fluid compartments.

作者信息

Harding J W, Sullivan M J, Hanesworth J M, Cushing L L, Wright J W

机构信息

Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman 99164-6520.

出版信息

J Neurochem. 1988 Feb;50(2):554-7. doi: 10.1111/j.1471-4159.1988.tb02946.x.

DOI:10.1111/j.1471-4159.1988.tb02946.x

PMID:3335860

Abstract

The angiotensin II competitive antagonist [125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection period following cerebroventricular infusion. These data suggest that angiotensins lack the capacity to move freely between the blood and cerebrospinal fluid compartments and are consistent with the notion that blood-borne and cerebroventricular angiotensins access different receptor populations.

摘要

血管紧张素II竞争性拮抗剂[125I]-Sar1，Ile8-血管紧张素II在完整或肾切除大鼠中均未从血管间隙转运至脑室间隙。此外，[125I]Sar1，Ile8-血管紧张素II在脑室注射后的20分钟收集期内缺乏反向移动的能力。这些数据表明血管紧张素缺乏在血液和脑脊液腔室之间自由移动的能力，并且与血源性和脑室血管紧张素作用于不同受体群体的观点一致。