Zhang Chengfang, Li Han, Yan Yabin, Zhang Xiyan, Tu Zhilan
Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China.
Clinical Research Center for Mental Disorders, Chinese-German Institute of Mental Health, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China.
Front Psychiatry. 2022 Jul 25;13:926251. doi: 10.3389/fpsyt.2022.926251. eCollection 2022.
A considerable number of patients suffer from adverse metabolic reactions caused by atypical antipsychotics (AAPs), however, current management strategies are disappointing to clinicians. Preclinical studies have consistently demonstrated that intermittent fasting (IF) has robust disease-modifying efficacy in animal models in a wide range of pathological conditions, especially obesity and diabetes. However, it is unclear what role IF can play in addressing AAPs-induced metabolic disturbances. In our study, we found that a 5:2 IF regimen significantly ameliorated the metabolic disturbances induced by olanzapine (a drug representative of AAPs) in animal models. Meanwhile, our research suggests that IF altering food intake during the refeeding phase may account for the metabolic benefit. This study provides supporting evidence regarding a potentially cost-effective intervention strategy for AAPs-induced metabolic disturbances.
相当多的患者遭受非典型抗精神病药物（AAPs）引起的不良代谢反应，然而，目前的管理策略令临床医生失望。临床前研究一直表明，间歇性禁食（IF）在广泛的病理状况下，尤其是肥胖和糖尿病的动物模型中具有强大的疾病改善功效。然而，尚不清楚间歇性禁食在解决AAPs引起的代谢紊乱中能发挥什么作用。在我们的研究中，我们发现5:2间歇性禁食方案显著改善了动物模型中由奥氮平（一种AAPs的代表性药物）引起的代谢紊乱。同时，我们的研究表明，间歇性禁食在重新进食阶段改变食物摄入量可能是代谢获益的原因。这项研究为AAPs引起的代谢紊乱提供了一种潜在的具有成本效益的干预策略的支持证据。
