Kamr Ahmed, Arbaga Ali, El-Bahrawy Amanallah, Elsify Ahmed, Khaled Hadeer, Hassan Hany
Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
Vet World. 2020 Nov;13(11):2371-2380. doi: 10.14202/vetworld.2020.2371-2380. Epub 2020 Nov 9.
Staphylococcus pyoderma is a common problem in dogs that need a novel treatment rather than antibiotic therapy. The aim of this study was to investigate the therapeutic efficacy, anti-inflammatory, and antioxidative properties of () gel ointment on dogs' Staphylococcus pyoderma compared to gentamicin ointment.
The inhibition zone of extract 20% and 40% and gentamicin 1% against was determined on well diffusion agar. Twenty Baladi local breed dogs were used as control negative group before intradermal inoculation with 10 CFU . The animals were classified into four equal groups, control positive group without treatment (n=5), treated groups by 20% gel ointment (n=5), 40% gel ointment (n=5), and gentamicin ointment 1% (n=5). Topical application of and gentamicin ointments was carried out twice daily for 2 weeks until complete healing of dogs' pyoderma. Clinical evaluation was recorded. Inflammatory, oxidant, and antioxidant parameters were measured in serum.
The inhibition zone of extracts 20% and 40% was 19 mm and 23 mm, respectively, while gentamicin 1% was 18 mm. The half maximal inhibitory concentration (of 20% and 40% were 13.70 with R=0.98. Dogs' pyoderma treated with gel ointment 20% and 40% were more likely to have low haptoglobin and tumor necrosis factor-α concentrations than gentamicin 1% ([odds ratio [OR]=4.6; 95% confidence interval [CI]=1.31-17.40; p<0.05]; [OR=5.2; 95% CI=1.04-22.30; p<0.05]), respectively.
It seems evident that has therapeutic effect, antibacterial, and anti-inflammatory effects against dogs' staphylococcal pyoderma than gentamicin that would support its further use rather than antibiotics in one health arena.
脓皮病葡萄球菌感染在犬类中是一个常见问题，需要一种新型治疗方法而非抗生素治疗。本研究的目的是比较（）凝胶软膏与庆大霉素软膏对犬脓皮病葡萄球菌感染的治疗效果、抗炎和抗氧化特性。
在琼脂平板扩散法中测定20%和40%的提取物以及1%庆大霉素对（）的抑菌圈。20只巴莱迪本地品种犬在皮内接种10CFU（）之前作为阴性对照组。将动物分为四组，每组数量相等，未治疗的阳性对照组（n = 5），20%（）凝胶软膏治疗组（n = 5），40%（）凝胶软膏治疗组（n = 5），以及1%庆大霉素软膏治疗组（n = 5）。每天两次局部应用（）和庆大霉素软膏，持续2周，直至犬脓皮病完全愈合。记录临床评估情况。测定血清中的炎症、氧化和抗氧化参数。
20%和40%的提取物的抑菌圈分别为19毫米和23毫米，而1%庆大霉素的抑菌圈为18毫米。20%和40%的（）的半数最大抑制浓度（）分别为13.70，相关系数R = 0.98。与1%庆大霉素相比，用20%和40%（）凝胶软膏治疗的犬脓皮病更有可能具有较低的触珠蛋白和肿瘤坏死因子-α浓度（[优势比[OR]=4.6；95%置信区间[CI]=1.31 - 17.40；p<0.05]；[OR = 5.2；95% CI = 1.04 - 22.30；p<0.05]）。
显然，（）对犬葡萄球菌性脓皮病具有治疗作用、抗菌和抗炎作用，比庆大霉素更具优势，这将支持其在“同一健康”领域进一步替代抗生素使用。
