Berkenbrock José Alvim, Grecco-Machado Rafaela, Achenbach Sven
Department of Electrical and Computer Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK, Canada.
Proc Math Phys Eng Sci. 2020 Nov;476(2243):20200398. doi: 10.1098/rspa.2020.0398. Epub 2020 Nov 4.
Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity.
对人群进行广泛的新冠病毒检测被认为是控制这种传染病传播、避免社会、医疗和经济系统进一步混乱的一项具有变革性的任务。尽管如此，对数以百万计的人进行新病毒检测带来了不少挑战。开发针对新型冠状病毒的有效检测方法已成为一项全球性任务，这依赖于近期的发现以及从以往疫情中吸取的经验教训。在这项工作中，我们回顾了关于用于病毒检测的微流控设备的最新出版物。讨论的主题包括不同的检测方法、信号传导方法和制造技术。除了传统台式检测方法的小型化，还考虑了电化学分析、场效应晶体管和电阻脉冲传感器等方法。对于快速检测试剂盒的应急制造，必须评估当地的能力，而且大学、产业界和政府的合作似乎是明确必要的。
