Pourteymour Fard Tabrizi Fatemeh, Abbasalizad Farhangi Mahdieh, Vaezi Maryam, Hemmati Salar
Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Nutrition in Community, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Phytother Res. 2021 May;35(5):2594-2606. doi: 10.1002/ptr.6999. Epub 2020 Dec 23.
This trial evaluated the effects of thylakoid-rich spinach extract supplementation combined with a hypocaloric diet on body composition and serum levels of neopterin, chemerin, and omentin-1 in obese women with polycystic ovary syndrome (PCOS). In this randomized controlled trial, 48 obese women with PCOS, aged 20-45 years old, were recruited and randomly divided into thylakoid (n = 24) and placebo (n = 24) groups. They received a low-calorie diet with 5 g/day thylakoid-rich spinach extract or a low-calorie diet with 5 g/day placebo for 12 weeks. The mean age of the participants of the thylakoid group was 31.86 years, and the placebo group was 32.04 years. Thylakoid-rich spinach extract supplementation with a low-calorie diet increased serum levels of omentin-1 (10.90 vs. 3.87 ng/L; p < .001) and decreased fat mass (-5.19 vs. -1.35 kg; p < .001) and serum levels of neopterin (-0.66 vs. -0.38 nmol/L; p = .003) and chemerin (-41.24 vs. -11.26 ng/L; p < .001) in the thylakoid group compared to the placebo group. A significant improvement in omentin-1, chemerin, and neopterin by thylakoid-rich spinach extract supplementation was under the influence of weight change and insulin resistance status throughout the study. A significant decrease in the other anthropometric indices and insulin resistance was also observed in the thylakoid group, compared to the placebo group (p < .001, for all parameters). Thylakoid-rich spinach extract combined with a low-calorie diet increased circulating omentin-1 and decreased fat mass, abdominal obesity, as well as circulating chemerin, neopterin, and insulin in obese women with PCOS.
本试验评估了富含类囊体的菠菜提取物补充剂联合低热量饮食对多囊卵巢综合征（PCOS）肥胖女性身体成分以及新蝶呤、趋化素和网膜素-1血清水平的影响。在这项随机对照试验中，招募了48名年龄在20至45岁之间的PCOS肥胖女性，并将她们随机分为类囊体组（n = 24）和安慰剂组（n = 24）。她们接受了每日5克富含类囊体的菠菜提取物的低热量饮食或每日5克安慰剂的低热量饮食，为期12周。类囊体组参与者的平均年龄为31.86岁，安慰剂组为32.04岁。与安慰剂组相比，富含类囊体的菠菜提取物补充剂联合低热量饮食使类囊体组的网膜素-1血清水平升高（10.90对3.87 ng/L；p <.001），脂肪量减少（-5.19对-1.35 kg；p <.001），新蝶呤血清水平降低（-0.66对-0.38 nmol/L；p =.003），趋化素血清水平降低（-41.24对-11.26 ng/L；p <.001）。在整个研究过程中，富含类囊体的菠菜提取物补充剂对网膜素-1、趋化素和新蝶呤的显著改善受到体重变化和胰岛素抵抗状态的影响。与安慰剂组相比，类囊体组的其他人体测量指标和胰岛素抵抗也显著降低（所有参数p <.001）。富含类囊体的菠菜提取物联合低热量饮食可提高PCOS肥胖女性的循环网膜素-1水平，减少脂肪量、腹部肥胖，以及降低循环趋化素、新蝶呤和胰岛素水平。
