Division of Microbiology and Tissue Culture, School of Life Sciences, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysuru, Karnataka, India.
J Appl Microbiol. 2021 Sep;131(3):1056-1071. doi: 10.1111/jam.14982. Epub 2021 Jan 7.
Resistance to antibiotics is an ongoing problem in the biomedical industry. Developing active, alternative drug therapies would reduce our reliance on antibiotics that induce resistance in micro-organisms. To date, bacteriocins and antimicrobial peptides have shown a positive outcome as antibiotic substitutes and synergists apart from phage therapy, antibodies and probiotics. Bacteriocins are proteinaceous antimicrobial peptides synthesized by lactic acid bacteria extensively used as bio-preservatives and alternative to traditional antibiotics to overcome the problem of drug-resistant pathogens. Nonetheless, the use of bacteriocins has several limitations such as limited antimicrobial spectrum, requiring high dose, sensitivity to proteolytic enzymes, etc. Nanoparticles are one of the promising area of research explored to improve antimicrobial spectrum of bacteriocins. This review therefore highlights the recent developments and research pertaining to use of nanoparticles and bacteriocin conjugates to tackle the resistance crisis as well as its applications in food industry.
抗生素耐药性是生物医药行业面临的一个持续存在的问题。开发有效的、替代的药物疗法将减少我们对那些会诱导微生物产生耐药性的抗生素的依赖。迄今为止，除了噬菌体疗法、抗体和益生菌之外，细菌素和抗菌肽作为抗生素替代品和增效剂已经显示出积极的效果。细菌素是由乳酸杆菌合成的蛋白质抗菌肽，被广泛用作生物防腐剂，以替代传统抗生素，以克服耐药病原体的问题。然而，细菌素的使用有几个局限性，如抗菌谱有限、需要高剂量、对蛋白水解酶敏感等。纳米颗粒是一个有前途的研究领域，用于改善细菌素的抗菌谱。因此，本综述强调了使用纳米颗粒和细菌素缀合物来应对耐药危机的最新进展和研究，以及它们在食品工业中的应用。
