Agrawal Paridhi, Nikhade Pradnya, Patel Aditya, Mankar Nikhil, Sedani Shweta
Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, IND.
Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2022 Aug 11;14(8):e27876. doi: 10.7759/cureus.27876. eCollection 2022 Aug.
The commercially available protein-digesting enzyme bromelain is derived from the pineapple fruit or stem. Bromelain from fruit and stems are produced in different ways and has varied enzyme compositions. "Bromelain" often refers to the "stem bromelain". Bromelain is a combination of several thiol endopeptidases and others including various protease inhibitors, glucosidase, cellulase, phosphatase, peroxidase, and escharase. Studies conducted in both the lab and on animals show that bromelain has a variety of fibrinolytic, anti-edematous, antithrombotic, and anti-inflammatory effects. The body can absorb bromelain to a significant extent without it ceasing its proteolytic activity or having any negative side effects. Numerous therapeutic advantages of bromelain include wound debridement, improved drug absorption, and the management of sinusitis, bronchitis, angina pectoris, surgical trauma, and thrombophlebitis. Additionally, it treats numerous cardiovascular conditions, diarrhoea, and osteoarthritis. Bromelain also encourages apoptotic cell death and exhibits some anti-cancerous properties. This review compiles the crucial traits, medical and dental uses of bromelain as well as its potential mechanism of action.
市售的蛋白消化酶菠萝蛋白酶源自菠萝果实或茎部。果实和茎部的菠萝蛋白酶生产方式不同，酶的组成也各异。“菠萝蛋白酶”通常指的是“茎菠萝蛋白酶”。菠萝蛋白酶是几种巯基内肽酶与其他物质的组合，包括各种蛋白酶抑制剂、葡糖苷酶、纤维素酶、磷酸酶、过氧化物酶和焦痂酶。在实验室和动物身上进行的研究表明，菠萝蛋白酶具有多种纤溶、抗水肿、抗血栓和抗炎作用。人体能够在很大程度上吸收菠萝蛋白酶，而它不会停止其蛋白水解活性，也不会产生任何负面副作用。菠萝蛋白酶的众多治疗优势包括伤口清创、改善药物吸收，以及治疗鼻窦炎、支气管炎、心绞痛、手术创伤和血栓性静脉炎。此外，它还能治疗多种心血管疾病、腹泻和骨关节炎。菠萝蛋白酶还能促进凋亡性细胞死亡，并具有一些抗癌特性。本综述汇编了菠萝蛋白酶的关键特性、医学和牙科用途及其潜在作用机制。
