Division of Hematology/Oncology, Children's Hospital of Michigan.
Department of Pediatrics, Central Michigan University, Mount Pleasant, MI.
J Pediatr Hematol Oncol. 2021 Nov 1;43(8):e1241-e1243. doi: 10.1097/MPH.0000000000002037.
The Coronavirus Disease 2019 (COVID-19) pandemic has become the worst pandemic in modern history. The lack of prior immunity to the virus has resulted in a high mortality rate, though children have fared better than adults, overall. We present a case of a child who developed B-cell acute lymphoblastic leukemia 1 week following a symptomatic COVID-19 infection. It is possible that this viral infection provided the "second hit" posited to occur in pediatric leukemogenesis as proposed by Dr Greaves, with his initial viral exposure occurring several weeks earlier.
2019 年冠状病毒病（COVID-19）大流行已成为现代史上最严重的大流行。由于人们对该病毒缺乏先前的免疫力，导致死亡率很高，不过总体而言，儿童的情况好于成年人。我们报告了一例儿童病例，该患儿在出现有症状的 COVID-19 感染 1 周后发展为 B 细胞急性淋巴细胞白血病。这种病毒感染可能提供了 Greaves 博士提出的儿科白血病发生中所谓的“二次打击”，而他最初的病毒暴露发生在几周前。
