Borowsky R
Department of Biology, New York University, Washington Square 10003.
Am J Hum Genet. 1988 Jan;42(1):132-4.
In cases of disputed paternity, blood tests are often used to obtain an estimate of the probability that the accused male is the true father. The interpretation of the genetic data is usually based upon a statistic called the paternity index. This paper shows that the paternity index method cannot be applied to data from compound loci in the absence of information on linkage phase. Since phenotypic data from compound loci, such as HLA, MNSs, and Rh, are often useful in disputed paternity proceedings, they should be analyzed with available alternative statistics.
在亲子关系有争议的情况下，血液检测常被用于估算被指控男性是孩子生父的概率。基因数据的解读通常基于一种名为父权指数的统计量。本文表明，在缺乏连锁相信息的情况下，父权指数法不能应用于复合基因座的数据。由于来自复合基因座的表型数据，如人类白细胞抗原（HLA）、MNSs血型系统和Rh血型系统的数据，在亲子关系争议诉讼中常常有用，因此应该用可用的替代统计方法对其进行分析。
