埃森-默勒亲权概率的实证验证。
Empirical validation of the Essen-Möller probability of paternity.
作者信息
Mickey M R, Gjertson D W, Terasaki P I
出版信息
Am J Hum Genet. 1986 Jul;39(1):123-32.
The validity of the Essen-Möller formulation probability of paternity is supported by demonstrating its correctness in a model genetic system--the ABO system. An analysis was made of 1,393 paternity cases typed uniformly for HLA-A and -B, ABO, Rh, and MNSs, in which the mother named one man only as the child's father and in which both mother and putative father identified themselves as Caucasian. For purposes of analysis, putative fathers not excluded from paternity by the four systems tested were regarded as actual fathers. The joint distribution of observed triplets of ABO phenotypes is shown to be statistically consistent with expected values, and the fractions of "true" fathers for a given triplet closely approximated the probability of paternity calculated using a realistic prior probability. Recent allegations of fallaciousness of the method by Li and Chakravarty and Aickin are discussed in terms of the results presented.
通过在一个模型遗传系统——ABO系统中证明其正确性，埃森-默勒父子关系概率公式的有效性得到了支持。对1393例亲子鉴定案例进行了分析，这些案例均对HLA-A和 -B、ABO、Rh以及MNSs进行了分型，其中母亲只指认一名男子为孩子的父亲，且母亲和推定父亲均表明自己为白种人。为了进行分析，在经过测试的四个系统中未被排除亲子关系的推定父亲被视为实际父亲。观察到的ABO血型三联体的联合分布在统计学上与预期值一致，对于给定的三联体，“真正”父亲的比例与使用实际先验概率计算出的父子关系概率非常接近。根据所呈现的结果，讨论了李、查克拉瓦蒂和艾金最近对该方法错误性的指控。
Zotero 插件