儿童和青少年的饮食行为、生化及生活方式因素与肥胖代谢表型的关联
Association of dietary behaviors, biochemical, and lifestyle factors with metabolic phenotypes of obesity in children and adolescents.
作者信息
Qorbani Mostafa, Khashayar Pouria, Rastad Hadith, Ejtahed Hanieh-Sadat, Shahrestanaki Ehsan, Seif Ehsan, Daniali Seyede Shahrbanoo, Goudarzi Masoomeh, Motlagh Mohammad Esmaeil, Khodaparast Zeinab, Heshmat Ramin, Kelishadi Roya
机构信息
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, No. 111, 19th St., North Kargar Ave, Tehran, Iran.
出版信息
Diabetol Metab Syndr. 2020 Dec 7;12(1):108. doi: 10.1186/s13098-020-00617-0.
BACKGROUND AND AIMS
To examine the association of dietary behaviors, lifestyle, and biochemical factors with metabolic phenotypes of obesity among obese Iranian children and adolescents.
METHODS
This cross-sectional study was conducted within the framework of the fifth phase of CASPIAN study. Of 3840 students aged 7-18 years of 30 Iranian provinces, 408 subjects were diagnosed as obese; they were divided into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) groups. Biochemical factors, anthropometric measures, dietary, and lifestyle habits were compared between groups.
RESULTS
Of the 408 obese subjects, 68 (16.7%) were the MUO; the remaining 340 (84.3%) fall in the MHO group. The MUO group had significantly higher systolic and diastolic BPs, FBS, TG, ALT, anthropometric measures, and lower HDL levels than MHO groups (all p-value < 0.05). The frequency of high birth weight (> 4000 gr) was significantly higher in the MUO group than the MHO group (p-value: 0.04). A higher percentage of individuals with breastfeeding duration ≥ 6 month was found in the MUO group (95.5% (95% CI 86.1-98.6%)) compared to MHO group (85.7% (95% CI 80.4-89.7%)) (p-value = 0.04). Among dietary and lifestyle-related behaviors, only the frequency of salty snack consumption and eating food according to the parents' request was significantly higher in the MUO group than the MHO group (p-value < 0.05).
CONCLUSION
Dietary habits and lifestyle factors may determine the obesity phenotypes in children and adolescents.
背景与目的
研究伊朗肥胖儿童和青少年的饮食行为、生活方式及生化因素与肥胖代谢表型之间的关联。
方法
本横断面研究在CASPIAN研究第五阶段的框架内进行。在伊朗30个省份的3840名7至18岁学生中，408名被诊断为肥胖；他们被分为代谢健康肥胖（MHO）组和代谢不健康肥胖（MUO）组。比较两组之间的生化因素、人体测量指标、饮食和生活习惯。
结果
在408名肥胖受试者中，68名（16.7%）为MUO；其余340名（84.3%）属于MHO组。MUO组的收缩压和舒张压、空腹血糖、甘油三酯、谷丙转氨酶、人体测量指标显著高于MHO组，高密度脂蛋白水平低于MHO组（所有p值<0.05）。MUO组高出生体重（>4000克）的频率显著高于MHO组（p值：0.04）。与MHO组（85.7%（95%CI 80.4-89.7%））相比，MUO组母乳喂养持续时间≥6个月的个体比例更高（95.5%（95%CI 86.1-98.6%））（p值=0.04）。在与饮食和生活方式相关的行为中，只有MUO组食用咸味零食的频率和按照父母要求进食的频率显著高于MHO组（p值<0.05）。
结论
饮食习惯和生活方式因素可能决定儿童和青少年的肥胖表型。
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