Department of Food Science and Engineering, Ningbo University, Ningbo 315211, PR China.
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, United States.
Int J Biol Macromol. 2021 Feb 15;170:336-342. doi: 10.1016/j.ijbiomac.2020.12.164. Epub 2020 Dec 26.
As an invisible organ of human body, the gut microbiota plays an important role in human life and has become a hot spot in the field of life science in recent years. Due to the increasing pressure of work and life, people are prone to depression. The in-depth mechanism studies indicated that the gut microbiota could improve the depression symptom through the gut-brain axis (GBA). As unique plant polysaccharides, dietary fiber can effectively modulate the intestinal flora disorders and its crucial role in orchestrating host-microbiota crosstalk has been confirmed. This review highlights the mechanisms that the gut microbiota affects the development of depression through GBA and focuses on dietary fiber intervention on the improvement of intestinal microbiota imbalance, which may provide new ideas for the prevention and treatment of depression.
作为人体的一个无形器官，肠道微生物群在人类生活中发挥着重要作用，近年来已成为生命科学领域的一个热点。由于工作和生活压力的增加，人们容易患抑郁症。深入的机制研究表明，肠道微生物群可以通过肠道-大脑轴（GBA）改善抑郁症状。膳食纤维作为独特的植物多糖，可以有效地调节肠道菌群紊乱，其在调控宿主-微生物群相互作用中的关键作用已得到证实。本综述强调了肠道微生物群通过 GBA 影响抑郁症发展的机制，并重点介绍了膳食纤维干预改善肠道微生物群失衡的作用，这可能为抑郁症的预防和治疗提供新的思路。
