Amway (China) R&D Centre Co., Ltd., Guangzhou 510730, China.
Ningbo Tech-inno Health Industry Co., Ltd., Ningbo 315211, China.
Molecules. 2022 Jun 7;27(12):3671. doi: 10.3390/molecules27123671.
The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their quality of life. The gut-brain axis (GBA) is closely related to the pathological basis of depression, and intestinal microbiota can improve depressive symptoms through GBA. Previous studies have proven that prebiotics can modulate intestinal microbiota and thus participate in human health regulation. We reviewed the regulatory mechanism of intestinal microbiota on depression through GBA, and discussed the effects of prebiotics, including plant polysaccharides and polyphenols on the regulation of intestinal microbiota, providing new clues for the prevention and treatment of depression.
肠道微生物失衡会导致内毒素在人体主要循环系统中积累，这对人类健康有很大影响。工作和生活压力的增加导致越来越多的人陷入抑郁，这也降低了他们的生活质量。肠脑轴（GBA）与抑郁症的病理基础密切相关，肠道微生物群可以通过 GBA 改善抑郁症状。先前的研究已经证明，益生元可以调节肠道微生物群，从而参与人体健康调节。我们通过 GBA 综述了肠道微生物群对抑郁症的调节机制，并讨论了包括植物多糖和多酚在内的益生元对肠道微生物群调节的影响，为抑郁症的预防和治疗提供了新的线索。
