Epigenetic Modifiers Affect the Bioactive Compounds Secreted by an Endophyte of the Tropical Plant .

Seven endophytic fungi were isolated from the tropical medicinal plant L. After preliminary screening, was selected for the epigenetic activation treatments. The antibacterial, antifungal, and antioxidant potentials of crude extracts obtained from the treatments (with and without epigenetic modifiers) were analyzed in vitro. The extracts inhibited growth of the human pathogens , and , as well as the phytopathogens , and . Furthermore, DPPH-scavenging activity was higher in valproic acid treated extracts. Volatile chemicals with known biological activities (measured with GC-MS/MS), were released in the valproic acid treatment. The antimicrobial potentials of the extracts were confirmed using MRM/MS analysis. The experiments revealed a new promising endophytic fungus, , to be utilized in biological plant protection and in biomedical applications.