Duan Jingzhu, Yang Yang, Zhang Erlin, Wang Huan
Department of Orthopaedic, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, China.
Department of Ophthalmology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, China.
Burns Trauma. 2020 Dec 21;8:tkaa036. doi: 10.1093/burnst/tkaa036. eCollection 2020.
Co-Cr-Mo alloy has been widely used in clinical implants because of its excellent mechanical and anti-corrosion properties, but there is an urgent need to address its disadvantages, such as implant-related infections and implant loosening. We synthesized Co-Cr-Mo-Cu (Co-Cu) alloys with different Cu contents to modify implant performance to be suitable as a bone-compatible implant material.
Microstructure, phase content and mechanical properties of the Co-Cr-Mo alloy were characterized. Histological and immunohistochemical analyses were performed after implantation in rabbits. The experimental alloy was implanted on the lateral side of the lower tibial condyle and the tibial nodule.
Phase content and mechanical properties revealed that the crystallographic structure and wear resistance were changed. Experimental implantation results demonstrated that osteogenic capability was markedly enhanced, ascribed to the excellent antibacterial and osseointegration capacities of Cu phases, and with the release of Cu ions. In particular, Co-Cu alloy containing 2 wt% Cu exhibited the best osteogenic performance among all samples.
The results indicated that osteogenic performance of the Co-Cr-Mo alloy could be enhanced by adding Cu. In particular, the Co-2Cu alloy exhibited the best properties according to both immunohistochemical and histological analyses. Our study not only provides deep insight into the osteogenic effect of Cu but presents a new Co-Cu alloy for clinical implants.
钴铬钼合金因其优异的机械性能和抗腐蚀性能而被广泛应用于临床植入物，但迫切需要解决其缺点，如植入物相关感染和植入物松动。我们合成了具有不同铜含量的钴铬钼铜（Co-Cu）合金，以改善植入物性能，使其适合作为骨相容性植入材料。
对钴铬钼合金的微观结构、相含量和机械性能进行了表征。在兔子体内植入后进行组织学和免疫组织化学分析。将实验合金植入胫骨外侧髁和胫骨结节。
相含量和机械性能表明，晶体结构和耐磨性发生了变化。实验植入结果表明，由于铜相具有优异的抗菌和骨整合能力以及铜离子的释放，成骨能力显著增强。特别是，含2 wt%铜的Co-Cu合金在所有样品中表现出最佳的成骨性能。
结果表明，添加铜可以增强钴铬钼合金的成骨性能。特别是，根据免疫组织化学和组织学分析，Co-2Cu合金表现出最佳性能。我们的研究不仅深入了解了铜的成骨作用，还提出了一种用于临床植入物的新型Co-Cu合金。
