Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University London, London, United Kingdom.
UKMS Register, Swansea University Medical School, Swansea, United Kingdom.
PLoS One. 2020 Dec 30;15(12):e0241459. doi: 10.1371/journal.pone.0241459. eCollection 2020.
The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.
People with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.
1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.
The UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.
维生素 D 缺乏与多发性硬化症（MS）之间的关联已有充分描述。我们旨在使用远程采样方法，在英国范围内的 MS 患者中进行横断面研究，以确定维生素 D 状态和维生素 D 补充情况。
在英国各地招募 MS 患者和匹配对照者。共有 1768 名 MS 患者参与了该研究；其中一个亚组被分配了远程采样工具包。通过干血斑（DBS）检测 MS 患者和对照者的血清 25（OH）D。
1768 名 MS 参与者完成了问卷调查；388 名 MS 参与者和 309 名对照者提供了生物样本。MS 患者的血清 25（OH）D 高于对照组（中位数 71nmol/L 比 49nmol/L）。MS 患者补充维生素 D 的比例高于对照组（72%比 26%，p<0.001）；MS 患者补充的维生素 D 剂量高于对照组（中位数 1600IU/天比 600IU/天，p<0.001）。未补充维生素 D 的 MS 患者血清 25（OH）D 水平低于未补充的对照组（中位数 38nmol/L 比 44nmol/L）。参与者对远程采样的参与度良好。
英国 MS 人群的血清 25（OH）D 水平高于对照组，这主要是由于维生素 D 补充。远程采样是进行大型研究的可行方法。
