Department of Gastroenterology, The Second Affiliated Hospital, Hainan Medical University, Haikou, 570311, Hainan, China.
Department of Gastroenterology, Cadre sanatorium of Hainan & Geriatric hospital of Hainan (CSH), Haikou, 571100, Hainan, China.
Hum Cell. 2021 Mar;34(2):539-549. doi: 10.1007/s13577-020-00464-1. Epub 2021 Jan 2.
Hepatocellular Carcinoma (HCC) is the second leading cause of cancer-related deaths. Neuroblastoma associated transcript 1 (NBAT1) is a newly identified long noncoding RNA (lncRNA), which has been reported to play an important role in human cancers. However, the functional role and underlying mechanism of NBAT1 in HCC remains unclear. Here, we found that the expression of NBAT1 was decreased in HCC tissues and cells; as well, the decreased expression of NBAT1 was also associated with tumor size and clinical TNM stages. NBAT1 overexpression, both in vitro and in vivo studies, inhibited tumorigenesis through apoptosis augmentation and cell cycle blockade. Mechanistically, NBAT1 bound to IGF2BP1 and inhibited the interaction between IGF2BP1 and c-Myc mRNA, thus suppressing the stability of c-Myc mRNA. Collectively, NBAT1 is associated with HCC tumorigenesis and could be a therapeutic target for HCC treatment.
肝细胞癌（HCC）是癌症相关死亡的第二大主要原因。神经母细胞瘤相关转录物 1（NBAT1）是一种新发现的长非编码 RNA（lncRNA），据报道其在人类癌症中发挥着重要作用。然而，NBAT1 在 HCC 中的功能作用及其潜在机制尚不清楚。在这里，我们发现 NBAT1 的表达在 HCC 组织和细胞中降低；并且，NBAT1 的表达降低与肿瘤大小和临床 TNM 分期有关。NBAT1 的过表达，无论是在体外还是体内研究中，均通过促进细胞凋亡和细胞周期阻滞抑制肿瘤发生。在机制上，NBAT1 与 IGF2BP1 结合并抑制 IGF2BP1 与 c-Myc mRNA 之间的相互作用，从而抑制 c-Myc mRNA 的稳定性。总之，NBAT1 与 HCC 的肿瘤发生有关，可能成为 HCC 治疗的一个潜在靶点。
