m6A甲基化修饰的写入器、擦除器和读取器在癌症中的作用。

Fang Zhen, Mei Wentong, Qu Chang, Lu Jiongdi, Shang Liang, Cao Feng, Li Fei

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Exp Hematol Oncol. 2022 Aug 9;11(1):45. doi: 10.1186/s40164-022-00298-7.

The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions.

N⁶-甲基腺苷（m⁶A）修饰是人类RNA中最普遍的修饰。近年来，越来越多的研究表明，m⁶A可能在癌症中发挥重要作用。许多研究已经证明，m⁶A参与癌细胞的生物学功能，如增殖、侵袭、转移和耐药性。此外，m⁶A与癌症患者的预后密切相关。在这篇综述中，我们重点介绍了在理解m⁶A在各种癌症中的功能方面的最新进展。我们强调m⁶A对癌症进展的重要性，并期待描述未来的研究方向。