Hadchouel M, Pasquinelli C, Fournier J G, Hugon R N, Scotto J, Bernard O, Brechot C
Inserm U 56, Hôpital de Bicêtre, France.
J Med Virol. 1988 Jan;24(1):27-32. doi: 10.1002/jmv.1890240105.
In situ hybridisation was used to detect RNA of Hepatitis B virus (HBV) in peripheral mononuclear blood cells. Presence of HBV-RNA was detected in 10/17 HBsAg positive HBeAg positive patients, in 8/18 HBsAg positive HBeAg negative patients, in 1/3 anti-HBs positive subjects. Four control subjects were negative. The frequency of labelled cells varied from 1 to 10% of mononuclear cells. These results indicate that the DNA detected so far in mononuclear blood cells may be transcriptionally active.
采用原位杂交法检测外周血单个核细胞中乙型肝炎病毒（HBV）的RNA。在17例HBsAg阳性HBeAg阳性患者中的10例、18例HBsAg阳性HBeAg阴性患者中的8例以及3例抗-HBs阳性受试者中的1例检测到HBV-RNA。4例对照受试者为阴性。标记细胞的频率在单个核细胞的1%至10%之间变化。这些结果表明，迄今为止在单个核血细胞中检测到的DNA可能具有转录活性。
