Department of Stomatology, Affiliated hospital of Jinggangshan University, Ji'an, 343000, China.
Cell Mol Biol (Noisy-le-grand). 2022 Feb 4;67(5):227-232. doi: 10.14715/cmb/2021.67.5.31.
Inflammatory markers play an important role in the pathophysiology of patients with oral problems such as oral lichen planus. This study aimed to investigate the relationship between vitamin D levels and inflammatory markers and total antioxidants in people with oral lichen planus. In this case-control study, 131 patients with oral lichen planus (67 in the lichen planus group and 54 in the control group) were examined. 8 cc of blood was taken from all participants to assess blood factors, inflammatory markers and antioxidant levels. Data were analyzed using SPSS statistical software. The mean age of subjects was 42 years. Vitamin D3 levels in the lichen planus group were lower than in the control group, but this decrease was not statistically significant (P> 0.05). According to statistical findings in the lichen planus group, there was a significant relationship between vitamin D3 levels, inflammatory markers and cellular stress factors (P≤0.05). It is concluded that vitamin D3 in people with oral lichen planus can play an important role in the pathogenesis of oral disease and increase inflammation. Because patients with oral lichen planus are affected by various inflammatory factors, paying attention to vitamin D levels in these patients can be effective in reducing inflammation caused by lichen planus.
炎症标志物在口腔问题（如口腔扁平苔藓）患者的病理生理学中起着重要作用。本研究旨在探讨维生素 D 水平与炎症标志物和总抗氧化剂在口腔扁平苔藓患者中的关系。在这项病例对照研究中，检查了 131 名口腔扁平苔藓患者（67 名在扁平苔藓组，54 名在对照组）。从所有参与者中抽取 8 毫升血液，以评估血液因素、炎症标志物和抗氧化剂水平。使用 SPSS 统计软件分析数据。受试者的平均年龄为 42 岁。扁平苔藓组的维生素 D3 水平低于对照组，但这种降低没有统计学意义（P>0.05）。根据扁平苔藓组的统计结果，维生素 D3 水平与炎症标志物和细胞应激因素之间存在显著关系（P≤0.05）。结论是，口腔扁平苔藓患者体内的维生素 D3 可能在口腔疾病的发病机制中发挥重要作用，并增加炎症。由于口腔扁平苔藓患者受到各种炎症因素的影响，因此关注这些患者的维生素 D 水平可以有效减轻扁平苔藓引起的炎症。
