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细胞膜包被纳米颗粒在精准癌症治疗中的创新应用。

Innovative utilization of cell membrane-coated nanoparticles in precision cancer therapy.

作者信息

He Yiling, Zhang Shuquan, She Yaoguang, Liu Zhaoshan, Zhu Yalan, Cheng Qinzhen, Ji Xiaoyuan

机构信息

Department of Pharmacy Jinhua Municipal Central Hospital Jinhua Zhejiang China.

Department of Orthopedics Integrated Chinese and Western Medicine Hospital Tianjin University Tianjin China.

出版信息

Exploration (Beijing). 2024 Mar 21;4(6):20230164. doi: 10.1002/EXP.20230164. eCollection 2024 Dec.

DOI:10.1002/EXP.20230164
PMID:39713200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11655310/
Abstract

Cell membrane-coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within a cell membrane-derived coating, these nanoparticles combine the advantages of synthetic nanoparticles and natural cell membranes. This review provides a comprehensive overview of the recent advancements in utilizing CMNPs as effective drug delivery vehicles for cancer therapy. The synthesis and fabrication methods of CMNPs are comprehensively discussed. Various techniques, such as extrusion, sonication, and self-assembly, are employed to coat synthetic nanoparticles with cell membranes derived from different cell types. The cell membrane coating enables biocompatibility, reducing the risk of an immune response and enhancing the stability of the nanoparticles in the bloodstream. Moreover, functionalization strategies for CMNPs, primarily chemical modification, genetic engineering, and external stimuli, are highlighted. The presence of specific cell surface markers on the coated membrane allows targeted drug delivery to cancer cells and maximizes therapeutic efficacy. Preclinical studies utilizing CMNPs for cancer therapy demonstrated the successful delivery of various therapeutic agents, such as chemotherapeutic drugs, nucleic acids, and immunotherapeutic agents, using CMNPs. Furthermore, the article explores the future directions and challenges of this technology while offering insights into its clinical potential.

摘要

细胞膜包被纳米颗粒（CMNPs）最近已成为一种很有前景的癌症治疗平台。通过将治疗剂包裹在细胞膜衍生的包衣内，这些纳米颗粒结合了合成纳米颗粒和天然细胞膜的优点。本综述全面概述了利用CMNPs作为癌症治疗有效药物递送载体的最新进展。全面讨论了CMNPs的合成和制备方法。采用了各种技术，如挤压、超声处理和自组装，用源自不同细胞类型的细胞膜包被合成纳米颗粒。细胞膜包衣实现了生物相容性，降低了免疫反应的风险，并增强了纳米颗粒在血液中的稳定性。此外，还重点介绍了CMNPs的功能化策略，主要是化学修饰、基因工程和外部刺激。包被膜上特定细胞表面标志物的存在使得能够将药物靶向递送至癌细胞，并使治疗效果最大化。利用CMNPs进行癌症治疗的临床前研究表明，使用CMNPs成功递送了各种治疗剂，如化疗药物、核酸和免疫治疗剂。此外，本文探讨了该技术的未来方向和挑战，同时深入了解其临床潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/9ae5520436aa/EXP2-4-20230164-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/0d70923fcd43/EXP2-4-20230164-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/53946f375b2f/EXP2-4-20230164-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/ed0e65b24a52/EXP2-4-20230164-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/68aa03aad0f1/EXP2-4-20230164-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/e73534d4e8bc/EXP2-4-20230164-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/a09a10146c21/EXP2-4-20230164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/2cf5e05478c4/EXP2-4-20230164-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/c78212581bd3/EXP2-4-20230164-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/9ae5520436aa/EXP2-4-20230164-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/0d70923fcd43/EXP2-4-20230164-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/6ecc7232f822/EXP2-4-20230164-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/3945876afa73/EXP2-4-20230164-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/421968149e06/EXP2-4-20230164-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/53946f375b2f/EXP2-4-20230164-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/ed0e65b24a52/EXP2-4-20230164-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/68aa03aad0f1/EXP2-4-20230164-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/e73534d4e8bc/EXP2-4-20230164-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/a09a10146c21/EXP2-4-20230164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/2cf5e05478c4/EXP2-4-20230164-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/c78212581bd3/EXP2-4-20230164-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/922c/11655310/9ae5520436aa/EXP2-4-20230164-g018.jpg

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