• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鼠李糖脂糖脂生物表面活性剂：生物技术和生物医学领域的新兴趋势和有前途的策略。

Rhamnolipid the Glycolipid Biosurfactant: Emerging trends and promising strategies in the field of biotechnology and biomedicine.

机构信息

School of Biological and Environmental Sciences, Faculty of Sciences, Shoolini University, Solan, HP, 173229, India.

School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110 067, India.

出版信息

Microb Cell Fact. 2021 Jan 4;20(1):1. doi: 10.1186/s12934-020-01497-9.

DOI:10.1186/s12934-020-01497-9
PMID:33397389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7784359/
Abstract

Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa. Due to their non-toxicity, high biodegradability, low surface tension and minimum inhibitory concentration values, they have gained attention in various sectors like food, healthcare, pharmaceutical and petrochemicals. The ecofriendly biological properties of rhamnolipids make them potent materials to be used in therapeutic applications. RLs are also known to induce apoptosis and thus, able to inhibit proliferation of cancer cells. RLs can also act as immunomodulators to regulate the humoral and cellular immune systems. Regarding their antimicrobial property, they lower the surface hydrophobicity, destruct the cytoplasmic membrane and lower the critical micelle concentration to kill the bacterial cells either alone or in combination with nisin possibly due to their role in modulating outer membrane protein. RLs are also involved in the synthesis of nanoparticles for in vivo drug delivery. In relation to economic benefits, the post-harvest decay of food can be decreased by RLs because they prevent the mycelium growth, spore germination of fungi and inhibit the emergence of biofilm formation on food. The present review focuses on the potential uses of RLs in cosmetic, pharmaceutical, food and health-care industries as the potent therapeutic agents.

摘要

鼠李糖脂（RLs）是一种表面活性化合物，属于糖脂生物表面活性剂类，主要由铜绿假单胞菌产生。由于其无毒、高生物降解性、低表面张力和最低抑菌浓度值，它们在食品、医疗保健、制药和石化等各个领域引起了关注。鼠李糖脂的环保生物特性使它们成为治疗应用中的有效材料。RLs 还已知可诱导细胞凋亡，从而能够抑制癌细胞的增殖。RLs 还可以作为免疫调节剂，调节体液和细胞免疫系统。关于其抗菌特性，它们通过降低表面疏水性、破坏细胞质膜和降低临界胶束浓度来杀死细菌细胞，无论是单独使用还是与乳链菌肽联合使用，这可能是由于它们在调节外膜蛋白方面的作用。RLs 还参与了用于体内药物递送的纳米粒子的合成。就经济效益而言，RLs 可以减少食品的收获后腐烂，因为它们可以防止真菌的菌丝体生长、孢子发芽，并抑制生物膜在食品上的形成。本综述重点介绍了 RLs 在化妆品、制药、食品和医疗保健行业作为潜在治疗剂的用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/b5b61b83e9f7/12934_2020_1497_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/f5fa7d2252b5/12934_2020_1497_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/2f5f9885837a/12934_2020_1497_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/026fc7cae819/12934_2020_1497_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/9fbf15740ba2/12934_2020_1497_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/09fb5abda873/12934_2020_1497_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/363b49b15f21/12934_2020_1497_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/b86604d74005/12934_2020_1497_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/e90c904db956/12934_2020_1497_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/ed5ac47c6020/12934_2020_1497_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/fc0a6e65e725/12934_2020_1497_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/2c99befa7867/12934_2020_1497_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/b5b61b83e9f7/12934_2020_1497_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/f5fa7d2252b5/12934_2020_1497_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/2f5f9885837a/12934_2020_1497_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/026fc7cae819/12934_2020_1497_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/9fbf15740ba2/12934_2020_1497_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/09fb5abda873/12934_2020_1497_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/363b49b15f21/12934_2020_1497_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/b86604d74005/12934_2020_1497_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/e90c904db956/12934_2020_1497_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/ed5ac47c6020/12934_2020_1497_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/fc0a6e65e725/12934_2020_1497_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/2c99befa7867/12934_2020_1497_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ca/7784359/b5b61b83e9f7/12934_2020_1497_Fig12_HTML.jpg

相似文献

1
Rhamnolipid the Glycolipid Biosurfactant: Emerging trends and promising strategies in the field of biotechnology and biomedicine.鼠李糖脂糖脂生物表面活性剂：生物技术和生物医学领域的新兴趋势和有前途的策略。
Microb Cell Fact. 2021 Jan 4;20(1):1. doi: 10.1186/s12934-020-01497-9.
2
Structural characterization and surface activities of biogenic rhamnolipid surfactants from Pseudomonas aeruginosa isolate MN1 and synergistic effects against methicillin-resistant Staphylococcus aureus.从铜绿假单胞菌 MN1 中分离的生物源鼠李糖脂表面活性剂的结构表征及其表面活性和对耐甲氧西林金黄色葡萄球菌的协同作用。
Folia Microbiol (Praha). 2012 Nov;57(6):501-8. doi: 10.1007/s12223-012-0164-z. Epub 2012 May 29.
3
Glycolipid biosurfactants: Potential related biomedical and biotechnological applications.糖脂生物表面活性剂：潜在的相关生物医学和生物技术应用。
Carbohydr Res. 2015 Oct 30;416:59-69. doi: 10.1016/j.carres.2015.07.016. Epub 2015 Jul 31.
4
Biosurfactant coated silver and iron oxide nanoparticles with enhanced anti-biofilm and anti-adhesive properties.具有增强的抗生物膜和抗粘附性能的生物表面活性剂涂层银和氧化铁纳米粒子。
J Hazard Mater. 2019 Feb 15;364:441-448. doi: 10.1016/j.jhazmat.2018.10.049. Epub 2018 Oct 19.
5
Microbial Biosurfactants-an Ecofriendly Boon to Industries for Green Revolution.微生物生物表面活性剂——绿色革命中工业的环保福音。
Recent Pat Biotechnol. 2020;14(3):169-183. doi: 10.2174/1872208313666191212094628.
6
Exploring the potential of chitosan-based particles as delivery-carriers for promising antimicrobial glycolipid biosurfactants.探讨壳聚糖基颗粒作为有前途的抗菌糖脂生物表面活性剂的递送载体的潜力。
Carbohydr Polym. 2021 Feb 15;254:117433. doi: 10.1016/j.carbpol.2020.117433. Epub 2020 Nov 22.
7
Rapid and solitary production of mono-rhamnolipid biosurfactant and biofilm inhibiting pyocyanin by a taxonomic outlier Pseudomonas aeruginosa strain CR1.分类群异常的铜绿假单胞菌 CR1 快速且单独产生单鼠李糖脂生物表面活性剂和抑制生物膜形成的绿脓菌素。
J Biotechnol. 2020 Jan 10;307:98-106. doi: 10.1016/j.jbiotec.2019.11.004. Epub 2019 Nov 6.
8
Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene.鼠李糖脂和内酯型槐糖脂：用于口腔卫生的天然抗菌表面活性剂。
J Appl Microbiol. 2017 Nov;123(5):1111-1123. doi: 10.1111/jam.13550. Epub 2017 Oct 16.
9
Rhamnolipid biosurfactants: production and their potential in environmental biotechnology.鼠李糖脂生物表面活性剂：生产及其在环境生物技术中的潜力。
Adv Exp Med Biol. 2010;672:211-21. doi: 10.1007/978-1-4419-5979-9_16.
10
Rhamnolipids from non-pathogenic Burkholderia thailandensis E264: Physicochemical characterization, antimicrobial and antibiofilm efficacy against oral hygiene related pathogens.来自非致病性泰国伯克霍尔德菌E264的鼠李糖脂：对口腔卫生相关病原体的物理化学特性、抗菌和抗生物膜功效
N Biotechnol. 2017 May 25;36:26-36. doi: 10.1016/j.nbt.2016.12.009. Epub 2017 Jan 5.

引用本文的文献

1
Targeted-Produced Dirhamnolipids from Induce Antinociception in Mice.靶向产生的鼠李糖脂可诱导小鼠产生抗伤害感受作用。
ACS Omega. 2025 Aug 7;10(32):36056-36067. doi: 10.1021/acsomega.5c03648. eCollection 2025 Aug 19.
2
Sugar Esters of Fatty Acids: Chemo-Enzymatic Synthesis and Biological Activity.脂肪酸糖酯：化学酶法合成与生物活性
Molecules. 2025 Jul 25;30(15):3123. doi: 10.3390/molecules30153123.
3
Exploration of novel bioactive compounds from the microbiome of fish and shellfish as an alternative to replace antibiotic drugs in aquaculture farming.

本文引用的文献

1
Cytotoxic effects of mono- and di-rhamnolipids from Pseudomonas aeruginosa MR01 on MCF-7 human breast cancer cells.铜绿假单胞菌 MR01 单、二鼠李糖脂对 MCF-7 人乳腺癌细胞的细胞毒性作用。
Colloids Surf B Biointerfaces. 2019 Sep 1;181:943-952. doi: 10.1016/j.colsurfb.2019.06.058. Epub 2019 Jun 27.
2
Rhamnolipid nanoparticles for in vivo drug delivery and photodynamic therapy.用于体内药物递送和光动力疗法的鼠李糖脂纳米颗粒。
Nanomedicine. 2019 Jul;19:12-21. doi: 10.1016/j.nano.2019.03.015. Epub 2019 Apr 12.
3
The antibacterial activity of rhamnolipid biosurfactant is pH dependent.
探索来自鱼类和贝类微生物群的新型生物活性化合物，以替代水产养殖中的抗生素药物。
Gut Microbiome (Camb). 2025 May 14;6:e8. doi: 10.1017/gmb.2025.6. eCollection 2025.
4
Liposome-encapsulated antibiotics and biosurfactants: an effective strategy to boost biofilm eradication in cooling towers.脂质体包裹的抗生素和生物表面活性剂：一种增强冷却塔生物膜清除效果的有效策略。
Microb Cell Fact. 2025 Jun 18;24(1):135. doi: 10.1186/s12934-025-02746-5.
5
Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.通过群体感应介导的自润滑作用来抵抗生物膜形成的微观地形景观的组合发现。
Nat Commun. 2025 Jun 18;16(1):5295. doi: 10.1038/s41467-025-60567-x.
6
Optimizing Rhamnolipid Performance by Modulating the Expression of Fatty Acid Synthesis Genes and in PAO1.通过调节PAO1中脂肪酸合成基因的表达来优化鼠李糖脂性能。
Genes (Basel). 2025 Apr 28;16(5):515. doi: 10.3390/genes16050515.
7
Engineered bacteria as an orally administered anti-viral treatment and immunization system.工程菌作为一种口服抗病毒治疗和免疫接种系统。
Gut Microbes. 2025 Dec;17(1):2500056. doi: 10.1080/19490976.2025.2500056. Epub 2025 May 8.
8
Rhamnolipid-Modified PHB-Ectoine Nanoparticles for Multifunctional Skin Protection Against UVB, Irritation, and Bacteria.用于多功能皮肤防护紫外线、刺激和细菌的鼠李糖脂修饰的聚羟基丁酸酯-依克多因纳米颗粒
ACS Omega. 2025 Mar 17;10(12):12200-12213. doi: 10.1021/acsomega.4c10583. eCollection 2025 Apr 1.
9
Investigating the wettability of neem oil nanoemulsion as a green pesticide on leaf surfaces - optimizing formulation, assessing stability, and enhancing wettability.研究印楝油纳米乳液作为绿色农药在叶片表面的润湿性——优化配方、评估稳定性并提高润湿性。
RSC Adv. 2025 Mar 20;15(11):8645-8656. doi: 10.1039/d5ra00556f. eCollection 2025 Mar 17.
10
Effects of rhamnolipids on growth performance, gut barriers, antioxidant capacity, immune function, and gut microbiota in broiler chickens.鼠李糖脂对肉鸡生长性能、肠道屏障、抗氧化能力、免疫功能和肠道微生物群的影响。
Poult Sci. 2025 May;104(5):104919. doi: 10.1016/j.psj.2025.104919. Epub 2025 Feb 17.
鼠李糖脂生物表面活性剂的抗菌活性取决于 pH 值。
Food Res Int. 2019 Feb;116:737-744. doi: 10.1016/j.foodres.2018.09.005. Epub 2018 Sep 6.
4
Sodium chloride effect on the aggregation behaviour of rhamnolipids and their antifungal activity.氯化钠对鼠李糖脂聚集行为及其抗真菌活性的影响。
Sci Rep. 2017 Oct 10;7(1):12907. doi: 10.1038/s41598-017-13424-x.
5
Disruption of Staphylococcus aureus biofilms using rhamnolipid biosurfactants.利用鼠李糖脂生物表面活性剂破坏金黄色葡萄球菌生物膜。
J Dairy Sci. 2017 Oct;100(10):7864-7873. doi: 10.3168/jds.2017-13012. Epub 2017 Aug 17.
6
Microbial production of rhamnolipids: opportunities, challenges and strategies.鼠李糖脂的微生物生产：机遇、挑战与策略。
Microb Cell Fact. 2017 Aug 5;16(1):137. doi: 10.1186/s12934-017-0753-2.
7
Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene.鼠李糖脂和内酯型槐糖脂：用于口腔卫生的天然抗菌表面活性剂。
J Appl Microbiol. 2017 Nov;123(5):1111-1123. doi: 10.1111/jam.13550. Epub 2017 Oct 16.
8
Effects of rhamnolipids on microorganism characteristics and applications in composting: A review.鼠李糖脂对微生物特性的影响及其在堆肥中的应用：综述
Microbiol Res. 2017 Jul;200:33-44. doi: 10.1016/j.micres.2017.04.005. Epub 2017 Apr 13.
9
Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery.鼠李糖脂形成用于皮肤给药的载药纳米颗粒。
Eur J Pharm Biopharm. 2017 Jul;116:31-37. doi: 10.1016/j.ejpb.2016.12.013. Epub 2016 Dec 21.
10
Novel insights into biosynthesis and uptake of rhamnolipids and their precursors.对鼠李糖脂及其前体生物合成和摄取的新见解。
Appl Microbiol Biotechnol. 2017 Apr;101(7):2865-2878. doi: 10.1007/s00253-016-8041-3. Epub 2016 Dec 17.