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全基因组测序揭示了黄带虾虎鱼（Mugilogobius chulae）的性别决定和肝脏高脂肪储存机制。

Whole-genome sequencing reveals sex determination and liver high-fat storage mechanisms of yellowstripe goby (Mugilogobius chulae).

作者信息

Cai Lei, Liu Guocheng, Wei Yuanzheng, Zhu Yabing, Li Jianjun, Miao Zongyu, Chen Meili, Yue Zhen, Yu Lujun, Dong Zhensheng, Ye Huixin, Sun Wenjing, Huang Ren

机构信息

Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.

BGI Genomics, BGI-Shenzhen, Shenzhen, China.

出版信息

Commun Biol. 2021 Jan 4;4(1):15. doi: 10.1038/s42003-020-01541-9.

DOI:10.1038/s42003-020-01541-9
PMID:33398077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7782490/
Abstract

As a promising novel marine fish model for future research on marine ecotoxicology as well as an animal model of human disease, the genome information of yellowstripe goby (Mugilogobius chulae) remains unknown. Here we report the first annotated chromosome-level reference genome assembly for yellowstripe goby. A 20.67-cM sex determination region was discovered on chromosome 5 and seven potential sex-determining genes were identified. Based on combined genome and transcriptome data, we identified three key lipid metabolic pathways for high-fat accumulation in the liver of yellowstripe goby. The changes in the expression patterns of MGLL and CPT1 at different development stage of the liver, and the expansion of the ABCA1 gene, innate immune gene TLR23, and TRIM family genes may help in balancing high-fat storage in hepatocytes and steatohepatitis. These results may provide insights into understanding the molecular mechanisms of sex determination and high-fat storage in the liver of marine fishes.

摘要

作为未来海洋生态毒理学研究中一种有前景的新型海洋鱼类模型以及人类疾病的动物模型，黄带虾虎鱼（Mugilogobius chulae）的基因组信息仍然未知。在此，我们报告了首个黄带虾虎鱼的注释染色体水平参考基因组组装。在5号染色体上发现了一个20.67厘摩的性别决定区域，并鉴定出7个潜在的性别决定基因。基于基因组和转录组数据的组合，我们确定了黄带虾虎鱼肝脏中高脂肪积累的三个关键脂质代谢途径。肝脏不同发育阶段MGLL和CPT1表达模式的变化，以及ABCA1基因、先天免疫基因TLR23和TRIM家族基因的扩增，可能有助于平衡肝细胞中的高脂肪储存和脂肪性肝炎。这些结果可能为理解海洋鱼类性别决定和肝脏高脂肪储存的分子机制提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/25752366e270/42003_2020_1541_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/54bb0551dd45/42003_2020_1541_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/39757d10d15f/42003_2020_1541_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/aa1ae6a13eec/42003_2020_1541_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/25752366e270/42003_2020_1541_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/54bb0551dd45/42003_2020_1541_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/47cce564010d/42003_2020_1541_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/bd2746a44b7f/42003_2020_1541_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/afa3477db9fe/42003_2020_1541_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/39757d10d15f/42003_2020_1541_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/aa1ae6a13eec/42003_2020_1541_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/7782490/25752366e270/42003_2020_1541_Fig7_HTML.jpg

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