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9-羟基异莪术酮抑制 LPS 诱导的 RAW264.7 细胞中 NO 和炎症细胞因子的产生。

9‑Hydroxy‑isoegomaketone inhibits LPS‑induced NO and inflammatory cytokine production in RAW264.7 cells.

机构信息

Radiation Breeding Research Team, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup‑si, Jeollabuk‑do 56212, Republic of Korea.

College of Pharmacy, Yeungnam University, Gyengsan‑si, Gyeongsangbuk‑do 38541, Republic of Korea.

出版信息

Mol Med Rep. 2021 Mar;23(3). doi: 10.3892/mmr.2020.11820. Epub 2021 Jan 5.

DOI:10.3892/mmr.2020.11820
PMID:33398364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7809899/
Abstract

Isoegomaketone (IK) is a known component of that reportedly exhibits anti‑inflammatory, anti‑cancer and anti‑allergic properties. A novel compound known as 9‑HIK has been isolated from the extract of a radiation mutant var. using supercritical carbon dioxide. In the present study, 9‑HIK induced heme oxygenase‑1 (HO‑1) mRNA expression in RAW264.7 cells, with maximal levels observed 4 h after 9‑HIK treatment. In addition, 9‑HIK inhibited the mRNA and protein expression of pro‑inflammatory mediators, such as IL‑6 and interferon‑β, as well as the production of nitric oxide (NO) in lipopolysaccharide‑stimulated RAW264.7 cells. Furthermore, N‑acetyl‑L‑cysteine, a reactive oxygen species scavenger, inhibited NO production and HO‑1 mRNA expression levels through the nuclear factor erythroid 2‑related factor 2 pathway. Overall, 9‑HIK displayed anti‑inflammatory properties in LPS‑induced RAW264.7 cells via direct suppression of inflammatory mediators and HO‑1 induction.

摘要

异戈马酮（IK）是 的一种已知成分，据报道具有抗炎、抗癌和抗过敏特性。一种新型化合物 9-HIK 已从辐射突变体 的提取物中用超临界二氧化碳分离出来。在本研究中，9-HIK 在 RAW264.7 细胞中诱导血红素加氧酶-1（HO-1）mRNA 表达，在 9-HIK 处理后 4 小时观察到最大水平。此外，9-HIK 抑制了促炎介质如 IL-6 和干扰素-β的 mRNA 和蛋白表达，以及脂多糖刺激的 RAW264.7 细胞中一氧化氮（NO）的产生。此外，活性氧物质清除剂 N-乙酰-L-半胱氨酸通过核因子红细胞 2 相关因子 2 途径抑制 NO 产生和 HO-1 mRNA 表达水平。总体而言，9-HIK 通过直接抑制炎症介质和诱导 HO-1，在 LPS 诱导的 RAW264.7 细胞中显示出抗炎特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/cee621ee3ca7/mmr-23-03-11820-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/2eeaeece355f/mmr-23-03-11820-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/fd23d7b3105d/mmr-23-03-11820-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/3df58a6ce91a/mmr-23-03-11820-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/82c3e09a780b/mmr-23-03-11820-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/c059068d1350/mmr-23-03-11820-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/830fd9d553ef/mmr-23-03-11820-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/cee621ee3ca7/mmr-23-03-11820-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/2eeaeece355f/mmr-23-03-11820-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/fd23d7b3105d/mmr-23-03-11820-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/3df58a6ce91a/mmr-23-03-11820-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/82c3e09a780b/mmr-23-03-11820-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/c059068d1350/mmr-23-03-11820-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/830fd9d553ef/mmr-23-03-11820-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009d/7809899/cee621ee3ca7/mmr-23-03-11820-g06.jpg

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