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使用多波长算法的宽带X射线叠层成像术

Broadband X-ray ptychography using multi-wavelength algorithm.

作者信息

Yao Yudong, Jiang Yi, Klug Jeffrey, Nashed Youssef, Roehrig Christian, Preissner Curt, Marin Fabricio, Wojcik Michael, Cossairt Oliver, Cai Zhonghou, Vogt Stefan, Lai Barry, Deng Junjing

机构信息

Advanced Photon Source, Argonne National Laboratory, IL 60439, USA.

Mathematics and Computer Science Division, Argonne National Laboratory, IL 60439, USA.

出版信息

J Synchrotron Radiat. 2021 Jan 1;28(Pt 1):309-317. doi: 10.1107/S1600577520014708.

DOI:10.1107/S1600577520014708
PMID:33399582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7842233/
Abstract

Ptychography is a rapidly developing scanning microscopy which is able to view the internal structures of samples at a high resolution beyond the illumination size. The achieved spatial resolution is theoretically dose-limited. A broadband source can provide much higher flux compared with a monochromatic source; however, it conflicts with the necessary coherence requirements of this coherent diffraction imaging technique. In this paper, a multi-wavelength reconstruction algorithm has been developed to deal with the broad bandwidth in ptychography. Compared with the latest development of mixed-state reconstruction approach, this multi-wavelength approach is more accurate in the physical model, and also considers the spot size variation as a function of energy due to the chromatic focusing optics. Therefore, this method has been proved in both simulation and experiment to significantly improve the reconstruction when the source bandwidth, illumination size and scan step size increase. It is worth mentioning that the accurate and detailed information of the energy spectrum for the incident beam is not required in advance for the proposed method. Further, we combine multi-wavelength and mixed-state approaches to jointly solve temporal and spatial partial coherence in ptychography so that it can handle various disadvantageous experimental effects. The significant relaxation in coherence requirements by our approaches allows the use of high-flux broadband X-ray sources for high-efficient and high-resolution ptychographic imaging.

摘要

叠层成像术是一种快速发展的扫描显微镜技术,它能够以高于照明尺寸的高分辨率观察样品的内部结构。所实现的空间分辨率在理论上受剂量限制。与单色光源相比,宽带光源可以提供更高的通量;然而,这与这种相干衍射成像技术所需的相干性要求相冲突。在本文中,已开发出一种多波长重建算法来处理叠层成像术中的宽带宽问题。与混合态重建方法的最新进展相比,这种多波长方法在物理模型上更准确,并且还考虑了由于色差聚焦光学元件导致的光斑尺寸随能量的变化。因此,在模拟和实验中均已证明,当光源带宽、照明尺寸和扫描步长增加时,该方法能显著改善重建效果。值得一提的是,所提出的方法无需预先获得入射光束能谱的准确详细信息。此外,我们将多波长方法和混合态方法相结合,共同解决叠层成像术中的时间和空间部分相干性问题,以便它能够处理各种不利的实验效应。我们的方法对相干性要求的显著放宽使得能够使用高通量宽带X射线源进行高效高分辨率的叠层成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/ab752e2f2716/s-28-00309-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/7e3b8d372e83/s-28-00309-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/03621bd54e8e/s-28-00309-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/6c516af9ceac/s-28-00309-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/13af917ddae3/s-28-00309-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/0f202fe6e219/s-28-00309-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/780d9481a45f/s-28-00309-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/ab752e2f2716/s-28-00309-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/7e3b8d372e83/s-28-00309-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/03621bd54e8e/s-28-00309-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/6c516af9ceac/s-28-00309-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/13af917ddae3/s-28-00309-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/0f202fe6e219/s-28-00309-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/780d9481a45f/s-28-00309-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6e8/7842233/ab752e2f2716/s-28-00309-fig7.jpg

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本文引用的文献

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The Velociprobe: An ultrafast hard X-ray nanoprobe for high-resolution ptychographic imaging.速度探测器:一种用于高分辨率叠层成像的超快硬X射线纳米探测器。
Rev Sci Instrum. 2019 Aug;90(8):083701. doi: 10.1063/1.5103173.
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Correlative 3D x-ray fluorescence and ptychographic tomography of frozen-hydrated green algae.冷冻水合绿藻的相关 3D X 射线荧光和叠层相位衬度断层成像。
Sci Adv. 2018 Nov 2;4(11):eaau4548. doi: 10.1126/sciadv.aau4548. eCollection 2018 Nov.
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Iterative least-squares solver for generalized maximum-likelihood ptychography.
Light Sci Appl. 2024 Aug 26;13(1):213. doi: 10.1038/s41377-024-01581-4.
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Optical ptychography for biomedical imaging: recent progress and future directions [Invited].用于生物医学成像的光学叠层成像术:最新进展与未来方向 [特邀报告]
Biomed Opt Express. 2023 Jan 3;14(2):489-532. doi: 10.1364/BOE.480685. eCollection 2023 Feb 1.
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Material-specific high-resolution table-top extreme ultraviolet microscopy.特定材料的高分辨率桌面式极紫外显微镜。
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High-speed free-run ptychography at the Australian Synchrotron.澳大利亚同步加速器的高速自由运行叠层术。
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Phys Rev B. 2017 Mar 1;95(10). doi: 10.1103/PhysRevB.95.104111. Epub 2017 Mar 24.
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Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography.通过叠层X射线纳米断层扫描对细胞超微结构进行三维质量密度映射。
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