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结直肠腺癌中与自身免疫性脑炎相关的浆细胞浸润。

Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis.

机构信息

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, Germany.

出版信息

Ann Clin Transl Neurol. 2021 Feb;8(2):498-503. doi: 10.1002/acn3.51283. Epub 2021 Jan 5.

DOI:10.1002/acn3.51283
PMID:33400852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7886041/
Abstract

Paraneoplastic autoimmune encephalitis (PAE) represents a group of rare neurological syndromes associated with neoplastic diseases. Here, we report a case that multiple anti-neuronal antibodies were present in a patient with PAE who developed both small cell lung cancer and colorectal adenocarcinoma. Furthermore, the immunopathological investigation of the colorectal adenocarcinoma revealed the formation of abnormal neuronal antigens and a massive infiltration of plasma cells in the tumor tissue. These findings support the hypothesis that expression of neuronal antigens in neoplasm initiates autoimmune responses in PAE.

摘要

副肿瘤性自身免疫性脑炎 (PAE) 是一组与肿瘤性疾病相关的罕见神经综合征。在这里，我们报告了一例 PAE 患者，该患者同时患有小细胞肺癌和结直肠腺癌，体内存在多种抗神经元抗体。此外，对结直肠腺癌的免疫病理学研究显示，肿瘤组织中形成了异常的神经元抗原和大量浆细胞浸润。这些发现支持了这样一种假说，即在肿瘤中神经元抗原的表达引发了 PAE 中的自身免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3870/7886041/0082ce034411/ACN3-8-498-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3870/7886041/f11683cc9a31/ACN3-8-498-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3870/7886041/0082ce034411/ACN3-8-498-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3870/7886041/f11683cc9a31/ACN3-8-498-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3870/7886041/0082ce034411/ACN3-8-498-g002.jpg

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本文引用的文献

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Eur J Neurol. 2021 Feb;28(2):595-601. doi: 10.1111/ene.14596. Epub 2020 Nov 10.
2
Comprehensive meta-analysis reveals an association of the HLA-DRB1*1602 allele with autoimmune diseases mediated predominantly by autoantibodies.综合荟萃分析显示，HLA-DRB1*1602 等位基因与主要由自身抗体介导的自身免疫性疾病相关。
Autoimmun Rev. 2020 Jun;19(6):102532. doi: 10.1016/j.autrev.2020.102532. Epub 2020 Mar 29.
3
Aetiology and pathogenesis of paraneoplastic autoimmune disorders.
副肿瘤自身免疫性疾病的病因和发病机制。
Autoimmun Rev. 2020 Jan;19(1):102422. doi: 10.1016/j.autrev.2019.102422. Epub 2019 Nov 13.
4
Multiple co-existing antibodies in autoimmune encephalitis: A case and review of the literature.自身免疫性脑炎中存在多种共存抗体：病例报告及文献复习。
J Neuroimmunol. 2019 Dec 15;337:577084. doi: 10.1016/j.jneuroim.2019.577084. Epub 2019 Oct 15.
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Acta Neuropathol Commun. 2019 Mar 11;7(1):38. doi: 10.1186/s40478-019-0693-7.
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